Research workbench
Water refined solution structure of the human GRB7-SH2 domain in complex with the 10 amino acid peptide PY1139
Analyse Water refined solution structure of the human GRB7-SH2 domain in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2L4K
- Type
- protein
- Length
- 130 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Growth factor receptor-bound protein 7; Receptor tyrosine-protein kinase erbb-2
- EC
- 2.7.10.1
- UniProt
- Q14451, P04626
- Pockets
- 2 · best druggability 0.44
Structure
solution nmr · 2 distinct chains · 16% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Growth factor receptor-bound protein 7 | protein | 120 | 18% helix, 17% strand | Q14451 |
| B | Receptor tyrosine-protein kinase erbb-2 (EC 2.7.10.1) | protein | 10 | 0% helix, 0% strand | P04626 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 63 | 0.44 | 0.82 | 15 | empty |
| 2 | 93 | 0.41 | 0.77 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 710 Ų buried · 17 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (phosphorylation).
Compared structures
- 2L4K · Water refined solution structure of the human Grb7-SH2 domain in complex with the 10… · the same entry in another collection · chain A against A, TM-score 1.00
- Q14451 · AlphaFold monomer V2.0 prediction for growth factor receptor-bound protein 7 (Q14451) · a predicted model of the same protein · chain A against A, TM-score 0.59
- P04626 · AlphaFold monomer V2.0 prediction for receptor tyrosine-protein kinase erbb-2 (P04626) · a predicted model of the same protein · chain B against A, TM-score 0.32
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14451
- Every structure of UniProt P04626
- Elsewhere: RCSB PDB 2L4K · PDBe 2L4K · UniProt Q14451 · UniProt P04626
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