UniProt Q14451
Growth factor receptor-bound protein 7 (Q14451)
Growth factor receptor-bound protein 7 (UniProt Q14451): 28 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 21 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q14451
- Protein
- Growth factor receptor-bound protein 7
- Experimental structures
- 28
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 21 · 5 records with a druggable one
Structures
29 records of Q14451 in the MolNFT archive: 28 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1MW4 | Solution structure of the human Grb7-SH2 domain in complex with a 10 amino acid peptide pY1139 | solution nmr | A | — | — |
| 1MW4 | Solution structure of the human GRB7-SH2 domain in complex with a 10 amino acid peptide PY1139 | solution nmr | A | — | — |
| 1WGR | Solution Structure of the RA Domain of Human Grb7 Protein | solution nmr | A | — | — |
| 1WGR | Solution structure of the ra domain of human GRB7 protein | solution nmr | A | — | — |
| 2L4K | Water refined solution structure of the human Grb7-SH2 domain in complex with the 10 amino acid… | solution nmr | A | — | — |
| 2L4K | Water refined solution structure of the human GRB7-SH2 domain in complex with the 10 amino acid… | solution nmr | A | — | — |
| 2QMS | Crystal structure of a signaling molecule | x-ray diffraction | A, B, C, D | — | — |
| 2QMS | Crystal structure of a signaling molecule | x-ray diffraction | A, B, C, D | — | — |
| 3PQZ | Grb7 SH2 with peptide | x-ray diffraction | A, B, C, D | — | — |
| 3PQZ | GRB7 SH2 with peptide | x-ray diffraction | A, B, C, D | — | — |
| 4WWQ | Apo structure of the Grb7 SH2 domain | x-ray diffraction | A, B | — | — |
| 4WWQ | Apo structure of the GRB7 SH2 domain | x-ray diffraction | A, B | — | — |
| 4X6S | Grb7 SH2 domain with phosphotyrosine mimetic inhibitor peptide | x-ray diffraction | A, B | — | — |
| 4X6S | GRB7 SH2 domain with phosphotyrosine mimetic inhibitor peptide | x-ray diffraction | A, B | — | — |
| 5D0J | Grb7 SH2 with inhibitor peptide | x-ray diffraction | A, B, C, D | PO4 | 5 (best 0.46) |
| 5D0J | GRB7 SH2 with inhibitor peptide | x-ray diffraction | A, B, C, D | — | — |
| 5EEL | Grb7 SH2 with bicyclic peptide inhibitor | x-ray diffraction | A, B, C, D, E, F | NA | — |
| 5EEL | GRB7 SH2 with bicyclic peptide inhibitor | x-ray diffraction | A, B, C, D, E, F | — | — |
| 5EEQ | Grb7 SH2 with the G7-B1 bicyclic peptide inhibitor | x-ray diffraction | A, B | PO4 | — |
| 5EEQ | GRB7 SH2 with the G7-B1 bicyclic peptide inhibitor | x-ray diffraction | A, B | — | — |
| 5TYI | Grb7 SH2 with bicyclic peptide containing pY mimetic | x-ray diffraction | A, B, C, D | — | 1 (best 0.73) |
| 5TYI | GRB7 SH2 with bicyclic peptide containing py mimetic | x-ray diffraction | A, B, C, D | 99Y, 48V | — |
| 5U06 | Grb7-SH2 with bicyclic peptide inhibitor containing a pY mimetic | x-ray diffraction | A, B, C, D | K | 4 (best 0.71) |
| 5U06 | GRB7-SH2 with bicyclic peptide inhibitor containing a py mimetic | x-ray diffraction | A, B, C, D | 48V, K | — |
| 5U1Q | Grb7-SH2 with bicyclic peptide inhibitor | x-ray diffraction | A, B, C, D | CL | 3 (best 0.68) |
| 5U1Q | GRB7-SH2 with bicyclic peptide inhibitor | x-ray diffraction | A, B, C, D | 48V, CL | — |
| 7MP3 | Grb7-SH2 domain in complex with bicyclic peptide B8 | x-ray diffraction | A, B, C, D | — | 2 (best 0.56) |
| 7MP3 | GRB7-SH2 domain in complex with bicyclic peptide B8 | x-ray diffraction | A, B, C, D | 48V | — |
| Q14451 | AlphaFold monomer V2.0 prediction for growth factor receptor-bound protein 7 (Q14451) | predicted | A | — | 6 (best 0.79) |
Ligands
Experiment against prediction
- 4X6S chain A against the predicted model Q14451: TM-score 0.99, RMSD 0.46 Å
- 4X6S chain A against the predicted model Q14451: TM-score 0.99, RMSD 0.46 Å
- 5TYI chain D against the predicted model Q14451: TM-score 0.99, RMSD 0.45 Å
- 5TYI chain D against the predicted model Q14451: TM-score 0.99, RMSD 0.45 Å
- 5EEL chain D against the predicted model Q14451: TM-score 0.99, RMSD 0.45 Å
- 5EEL chain D against the predicted model Q14451: TM-score 0.99, RMSD 0.45 Å
- 4X6S chain B against the predicted model Q14451: TM-score 0.99, RMSD 0.49 Å
- 4X6S chain B against the predicted model Q14451: TM-score 0.99, RMSD 0.49 Å
- 5EEQ chain B against the predicted model Q14451: TM-score 0.98, RMSD 0.47 Å
- 5EEQ chain B against the predicted model Q14451: TM-score 0.98, RMSD 0.47 Å
Elsewhere
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