Research workbench
NMR solution structure of the PHI0 pki nes peptide in complex with CRM1-rangtp
Analyse NMR solution structure of the PHI0 pki nes peptide in complex with CRM1-rangtp in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2L1L
- Type
- protein
- Length
- 154 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Camp-dependent protein kinase inhibitor alpha; Exportin-1
- UniProt
- P61925, O14980
- Pockets
- 2 · best druggability 0.32
Structure
solution nmr · 2 distinct chains · 62% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Camp-dependent protein kinase inhibitor alpha | protein | 27 | 30% helix, 0% strand | P61925 |
| B | Exportin-1 | protein | 127 | 69% helix, 0% strand | O14980 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 63 | 0.32 | 0.75 | 17 | empty |
| 2 | 60 | 0.28 | 0.73 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 862 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 2L1L · NMR Solution Structure of the Phi0 PKI NES Peptide in Complex with CRM1-RanGTP · the same entry in another collection · chain A against A, TM-score 1.00
- O14980 · AlphaFold monomer V2.0 prediction for exportin-1 (O14980) · a predicted model of the same protein · chain B against A, TM-score 0.99
- P61925 · AlphaFold monomer V2.0 prediction for camp-dependent protein kinase inhibitor alpha… · a predicted model of the same protein · chain A against A, TM-score 0.32
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P61925
- Every structure of UniProt O14980
- Elsewhere: RCSB PDB 2L1L · PDBe 2L1L · UniProt P61925 · UniProt O14980
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