UniProt P61925
cAMP-dependent protein kinase inhibitor alpha (P61925)
cAMP-dependent protein kinase inhibitor alpha (UniProt P61925): 167 experimental structures and 1 predicted model on GenesisL1, 10 ligands bound, 43 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P61925
- Protein
- cAMP-dependent protein kinase inhibitor alpha
- Experimental structures
- 167
- Predicted models
- 1
- Ligands
- 10
- Pockets
- 43 · 21 records with a druggable one
Structures
168 records of P61925 in the MolNFT archive: 167 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1CDK | Camp-dependent protein kinase catalytic subunit (E.C.2.7.1.37) (protein kinase a) complexed with… | x-ray diffraction | I, J | — | — |
| 1CDK | Camp-dependent protein kinase catalytic subunit (E.C.2.7.1.37) (protein kinase a) complexed with… | x-ray diffraction | I, J | — | — |
| 1CMK | Crystal structures of the myristylated catalytic subunit of camp-dependent protein kinase reveal… | x-ray diffraction | I | — | — |
| 1CMK | Crystal structures of the myristylated catalytic subunit of camp- dependent protein kinase reveal… | x-ray diffraction | I | — | — |
| 1CTP | Structure of the mammalian catalytic subunit of camp-dependent protein kinase and an inhibitor… | x-ray diffraction | I | — | — |
| 1CTP | Structure of the mammalian catalytic subunit of camp-dependent protein kinase and an inhibitor… | x-ray diffraction | I | — | — |
| 1XH4 | Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and… | x-ray diffraction | B | — | — |
| 1XH4 | Crystal structures of protein kinase B selective inhibitors in complex with protein kinase a and… | x-ray diffraction | B | — | — |
| 1XH5 | Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and… | x-ray diffraction | B | — | — |
| 1XH5 | Crystal structures of protein kinase B selective inhibitors in complex with protein kinase a and… | x-ray diffraction | B | — | — |
| 1XH6 | Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and… | x-ray diffraction | B | — | — |
| 1XH6 | Crystal structures of protein kinase B selective inhibitors in complex with protein kinase a and… | x-ray diffraction | B | — | — |
| 1XH7 | Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and… | x-ray diffraction | B | — | — |
| 1XH7 | Crystal structures of protein kinase B selective inhibitors in complex with protein kinase a and… | x-ray diffraction | B | — | — |
| 1XH8 | Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and… | x-ray diffraction | B | — | — |
| 1XH8 | Crystal structures of protein kinase B selective inhibitors in complex with protein kinase a and… | x-ray diffraction | B | — | — |
| 1XH9 | Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and… | x-ray diffraction | B | — | — |
| 1XH9 | Crystal structures of protein kinase B selective inhibitors in complex with protein kinase a and… | x-ray diffraction | B | — | — |
| 1XHA | Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and… | x-ray diffraction | B | — | — |
| 1XHA | Crystal structures of protein kinase B selective inhibitors in complex with protein kinase a and… | x-ray diffraction | B | — | — |
| 1YDR | Structure of camp-dependent protein kinase, alpha-catalytic subunit in complex with H7 protein… | x-ray diffraction | I | — | — |
| 1YDR | Structure of camp-dependent protein kinase, alpha-catalytic subunit in complex with H7 protein… | x-ray diffraction | I | — | — |
| 2C1A | Structure of cAMP-dependent protein kinase complexed with Isoquinoline-5-sulfonic acid… | x-ray diffraction | I | — | — |
| 2C1A | Structure of camp-dependent protein kinase complexed with isoquinoline-5-sulfonic acid… | x-ray diffraction | I | — | — |
| 2C1B | Structure of cAMP-dependent protein kinase complexed with… | x-ray diffraction | I | — | — |
| 2C1B | Structure of camp-dependent protein kinase complexed with (4R,2S)-5'… | x-ray diffraction | I | — | — |
| 2JDS | Structure of cAMP-dependent protein kinase complexed with A-443654 | x-ray diffraction | I | — | — |
| 2JDS | Structure of camp-dependent protein kinase complexed with a- 443654 | x-ray diffraction | I | — | — |
| 2JDT | Structure of PKA-PKB chimera complexed with ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)… | x-ray diffraction | I | — | — |
| 2JDT | Structure of PKA-pkb chimera complexed with isoquinoline-5- sulfonic acid (2-(2-(4-chlorobenzyloxy)… | x-ray diffraction | I | — | — |
| 2JDV | Structure of PKA-PKB chimera complexed with A-443654 | x-ray diffraction | I | — | — |
| 2JDV | Structure of PKA-pkb chimera complexed with a-443654 | x-ray diffraction | I | — | — |
| 2L1L | NMR Solution Structure of the Phi0 PKI NES Peptide in Complex with CRM1-RanGTP | solution nmr | A | — | — |
| 2L1L | NMR solution structure of the PHI0 pki nes peptide in complex with CRM1-rangtp | solution nmr | A | — | — |
| 2UVX | Structure of PKA-PKB chimera complexed with 7-azaindole | x-ray diffraction | I | — | — |
| 2UVX | Structure of PKA-pkb chimera complexed with 7-azaindole | x-ray diffraction | I | — | — |
| 2UVY | Structure of PKA-PKB chimera complexed with methyl-(4-(9H-purin-6-yl)- benzyl)-amine | x-ray diffraction | I | — | — |
| 2UVY | Structure of PKA-pkb chimera complexed with methyl-(4-(9H- purin-6-yl)-benzyl)-amine | x-ray diffraction | I | — | — |
| 2UVZ | Structure of PKA-PKB chimera complexed with C-Phenyl-C-(4-(9H-purin-6- yl)-phenyl)-methylamine | x-ray diffraction | I | — | — |
| 2UVZ | Structure of PKA-pkb chimera complexed with C-phenyl-C-(4-( 9H-purin-6-yl)-phenyl)-methylamine | x-ray diffraction | I | — | — |
| 2UW0 | Structure of PKA-PKB chimera complexed with 6-(4-(4-(4-Chloro-phenyl)… | x-ray diffraction | I | — | — |
| 2UW0 | Structure of PKA-pkb chimera complexed with 6-(4-(4-(4… | x-ray diffraction | I | — | — |
| 2UW3 | Structure of PKA-PKB chimera complexed with 5-methyl-4-phenyl-1H- pyrazole | x-ray diffraction | I | — | — |
| 2UW3 | Structure of PKA-pkb chimera complexed with 5-methyl-4- phenyl-1H-pyrazole | x-ray diffraction | I | — | — |
| 2UW4 | Structure of PKA-PKB chimera complexed with 2-(4-(5-methyl-1H-pyrazol- 4-yl)-phenyl)-ethylamine | x-ray diffraction | I | — | — |
| 2UW4 | Structure of PKA-pkb chimera complexed with 2-(4-(5-methyl- 1H-pyrazol-4-yl)-phenyl)-ethylamine | x-ray diffraction | I | — | — |
| 2UW5 | Structure of PKA-PKB chimera complexed with (R)-2-(4-chloro-phenyl)… | x-ray diffraction | I | — | — |
| 2UW5 | Structure of PKA-pkb chimera complexed with (R)-2-(4… | x-ray diffraction | I | — | — |
| 2UW6 | Structure of PKA-PKB chimera complexed with (S)-2-(4-chloro-phenyl)… | x-ray diffraction | I | — | — |
| 2UW6 | Structure of PKA-pkb chimera complexed with (S)-2-(4… | x-ray diffraction | I | — | — |
| 2UW7 | Structure of PKA-PKB chimera complexed with 4-(4-chloro-phenyl)-4-(4… | x-ray diffraction | I | — | — |
| 2UW7 | Structure of PKA-pkb chimera complexed with 4-(4-chloro… | x-ray diffraction | I | — | — |
| 2UW8 | Structure of PKA-PKB chimera complexed with 2-(4-chloro-phenyl)-2- phenyl-ethylamine | x-ray diffraction | I | — | — |
| 2UW8 | Structure of PKA-pkb chimera complexed with 2-(4-chloro- phenyl)-2-phenyl-ethylamine | x-ray diffraction | I | — | — |
| 2VNW | Structure of PKA-PKB chimera complexed with (1-(9H-Purin-6-yl) piperidin-4-yl)methanamine | x-ray diffraction | I | — | — |
| 2VNW | Structure of PKA-pkb chimera complexed with (1-(9H-purin-6- YL)PIPERIDIN-4-YL)METHANAMINE | x-ray diffraction | I | — | — |
| 2VNY | Structure of PKA-PKB chimera complexed with (1-(9H-Purin-6-yl) piperidin-4-yl)amine | x-ray diffraction | I | — | — |
| 2VNY | Structure of PKA-pkb chimera complexed with (1-(9H-purin-6- YL)PIPERIDIN-4-YL)AMINE | x-ray diffraction | I | — | — |
| 2VO0 | Structure of PKA-PKB chimera complexed with C-(4-(4-Chlorophenyl)-1-(7H-pyrrolo(2,3-d)pyrimidin-4-yl… | x-ray diffraction | I | — | — |
| 2VO0 | Structure of PKA-pkb chimera complexed with C-(4-(4… | x-ray diffraction | I | — | — |
108 records more on the page itself.
Ligands
- 6TV · ~{N}-[2-(propylamino)ethyl]isoquinoline-5-sulfonamide · in 2 records
- 7KB · 5-(1,4-diazepan-1-ylsulfonyl)-4-methyl-isoquinoline · in 2 records
- ADP · Adenosine-5'-diphosphate · in 2 records
- E3Z · ~{N}-[3-[(5-chloranyl-2-phenylazanyl-pyrimidin-4-yl) amino]phenyl]prop-2-enamide · in 2 records
- IQP · 1-(5-isoquinolinesulfonyl)-2-methylpiperazine · in 2 records
- M77 · 5-(1,4-diazepan-1-sulfonyl)isoquinoline · in 2 records
- PO4 · Phosphate ion · in 2 records
- 6TX · 2-[isoquinolin-5-ylsulfonyl(propyl)amino]ethylazanium · in 1 record
- 7CB · isoquinoline-5-sulfonamide · in 1 record
- IQU · N-(2-aminoethyl)isoquinoline-5-sulfonamide · in 1 record
Experiment against prediction
- 6X2U chain D against the predicted model P61925: TM-score 0.75, RMSD 0.92 Å
- 6X2W chain D against the predicted model P61925: TM-score 0.62, RMSD 0.64 Å
- 5XOJ chain D against the predicted model P61925: TM-score 0.60, RMSD 1.48 Å
- 3WYG chain D against the predicted model P61925: TM-score 0.55, RMSD 1.63 Å
- 4IJ9 chain I against the predicted model P61925: TM-score 0.45, RMSD 1.52 Å
- 6E99 chain B against the predicted model P61925: TM-score 0.45, RMSD 1.66 Å
- 5M0L chain B against the predicted model P61925: TM-score 0.44, RMSD 1.60 Å
- 3OOG chain B against the predicted model P61925: TM-score 0.44, RMSD 1.55 Å
- 6E9L chain B against the predicted model P61925: TM-score 0.44, RMSD 1.59 Å
- 3OXT chain B against the predicted model P61925: TM-score 0.44, RMSD 1.54 Å
Elsewhere
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