UniProt O14980
Exportin-1 (O14980)
Exportin-1 (UniProt O14980): 16 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 54 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O14980
- Protein
- Exportin-1
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 54 · 4 records with a druggable one
Structures
17 records of O14980 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1W9C | Proteolytic fragment of CRM1 spanning six C-terminal HEAT repeats | x-ray diffraction | A, B | — | — |
| 1W9C | Proteolytic fragment of CRM1 spanning six C-terminal heat repeats | x-ray diffraction | A, B | — | — |
| 2L1L | NMR Solution Structure of the Phi0 PKI NES Peptide in Complex with CRM1-RanGTP | solution nmr | B | — | — |
| 2L1L | NMR solution structure of the PHI0 pki nes peptide in complex with CRM1-rangtp | solution nmr | B | — | — |
| 3GB8 | Crystal structure of CRM1/Snurportin-1 complex | x-ray diffraction | A | — | — |
| 3GB8 | Crystal structure of CRM1/SNURPORTIN-1 complex | x-ray diffraction | A | — | — |
| 4BSM | Crystal structure of the Nuclear Export Receptor CRM1 (exportin-1) lacking the C-terminal helical… | x-ray diffraction | A | — | — |
| 4BSM | Crystal structure of the nuclear export receptor CRM1 (exportin-1) lacking the C-terminal helical… | x-ray diffraction | A | — | — |
| 4BSN | Crystal structure of the Nuclear Export Receptor CRM1 (exportin-1) lacking the C-terminal helical… | x-ray diffraction | A | — | — |
| 4BSN | Crystal structure of the nuclear export receptor CRM1 (exportin-1) lacking the C-terminal helical… | x-ray diffraction | A | — | — |
| 5DIS | Crystal structure of a CRM1-RanGTP-SPN1 export complex bound to a 113 amino acid FG-repeat… | x-ray diffraction | A | GLC, PRO | 15 (best 0.86) |
| 5DIS | Crystal structure of a CRM1-rangtp-SPN1 export complex bound to a 113 amino acid fg-repeat… | x-ray diffraction | A | — | — |
| 6TVO | Human CRM1-RanGTP in complex with Leptomycin B | x-ray diffraction | A | LMB | 16 (best 0.86) |
| 6TVO | Human CRM1-rangtp in complex with leptomycin B | x-ray diffraction | A | LMB | — |
| 7B51 | Crystal structure of human CRM1 covalently modified by 2- mercaptoethanol at CYS528 | x-ray diffraction | A | — | — |
| 9B62 | Human RANBP2/RAN(GTP)/RANGAP1-SUMO1/UBC9/CRM1/RAN(GTP) - composite map and model | electron microscopy | A | — | 11 (best 0.85) |
| O14980 | AlphaFold monomer V2.0 prediction for exportin-1 (O14980) | predicted | A | — | 12 (best 0.66) |
Ligands
Experiment against prediction
- 6TVO chain A against the predicted model O14980: TM-score 0.99, RMSD 0.70 Å
- 6TVO chain A against the predicted model O14980: TM-score 0.99, RMSD 0.70 Å
- 9B62 chain A against the predicted model O14980: TM-score 0.99, RMSD 0.78 Å
- 7B51 chain A against the predicted model O14980: TM-score 0.99, RMSD 0.80 Å
- 2L1L chain B against the predicted model O14980: TM-score 0.99, RMSD 0.31 Å
- 2L1L chain B against the predicted model O14980: TM-score 0.99, RMSD 0.31 Å
- 5DIS chain A against the predicted model O14980: TM-score 0.99, RMSD 1.22 Å
- 5DIS chain A against the predicted model O14980: TM-score 0.99, RMSD 1.22 Å
- 1W9C chain A against the predicted model O14980: TM-score 0.94, RMSD 1.69 Å
- 1W9C chain A against the predicted model O14980: TM-score 0.94, RMSD 1.69 Å
Elsewhere
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