MolNFT v1 · #87164 · protein
Crystal structure of the nuclear export receptor CRM1 (exportin-1) lacking the C-terminal helical extension at 4.5A
4BSM: “Crystal structure of the nuclear export receptor CRM1 (exportin-1) lacking the C-terminal helical extension…”. X-ray diffraction, 6 pockets (best druggability 0.82). MolNFT v1 #87164 on GenesisL1: 3D structure, binding sites and…
- PDB
- 4BSM
- Type
- protein
- Length
- 896 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Exportin-1
- UniProt
- O14980
- Pockets
- 6 · best druggability 0.82
Structure
x-ray diffraction · 1 distinct chain · 72% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Exportin-1 | protein | 896 | 72% helix, 0% strand | O14980 |
Pockets
6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1017 | 0.82 | 0.83 | 98 | empty |
| 2 | 236 | 0.72 | 0.87 | 27 | empty |
| 3 | 115 | 0.53 | 0.82 | 21 | empty |
| 4 | 258 | 0.50 | 0.74 | 26 | empty |
| 5 | 79 | 0.46 | 0.81 | 17 | empty |
Compared structures
- 4BSM · Crystal structure of the Nuclear Export Receptor CRM1 (exportin-1) lacking the C-terminal… · the same entry in another collection · chain A against A, TM-score 1.00
- O14980 · AlphaFold monomer V2.0 prediction for exportin-1 (O14980) · a predicted model of the same protein · chain A against A, TM-score 0.82
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O14980
- Elsewhere: RCSB PDB 4BSM · PDBe 4BSM · UniProt O14980
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