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Crystal structure of the nuclear export receptor CRM1 (exportin-1) lacking the C-terminal helical extension at 4.5A

Analyse Crystal structure of the nuclear export receptor CRM1 (exportin-1) lacking the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4BSM
Type: protein
Length: 896 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Exportin-1
UniProt: O14980
Pockets: 6 · best druggability 0.82

Structure

x-ray diffraction · 1 distinct chain · 72% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Exportin-1	protein	896	72% helix, 0% strand	O14980

Pockets

6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1017	0.82	0.83	98	empty
2	236	0.72	0.87	27	empty
3	115	0.53	0.82	21	empty
4	258	0.50	0.74	26	empty
5	79	0.46	0.81	17	empty

Compared structures

4BSM · Crystal structure of the Nuclear Export Receptor CRM1 (exportin-1) lacking the C-terminal… · the same entry in another collection · chain A against A, TM-score 1.00
O14980 · AlphaFold monomer V2.0 prediction for exportin-1 (O14980) · a predicted model of the same protein · chain A against A, TM-score 0.82

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O14980
Elsewhere: RCSB PDB 4BSM · PDBe 4BSM · UniProt O14980

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