Research workbench

Solution structure of the 21 kda GTPase rheb bound to GDP

Analyse Solution structure of the 21 kda GTPase rheb bound to GDP in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2L0X
Type: protein
Length: 169 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: GTP-binding protein rheb
UniProt: Q62639
Ligands: GDP, MG
Pockets: 4 · best druggability 0.75

Structure

solution nmr · 1 distinct chain · 37% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	GTP-binding protein rheb	protein	169	37% helix, 25% strand	Q62639

Ligands and binding sites

GDP · Guanosine-5'-diphosphate · ligand · chains A
MG · Magnesium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	67	0.75	0.98	21	empty
2	62	0.48	0.84	16	empty
3	115	0.45	0.78	20	empty
4	105	0.37	0.75	28	GDP

Compared structures

2L0X · Solution structure of the 21 kDa GTPase RHEB bound to GDP · the same entry in another collection · chain A against A, TM-score 1.00
Q62639 · AlphaFold monomer V2.0 prediction for GTP-binding protein rheb (Q62639) · a predicted model of the same protein · chain A against A, TM-score 0.83

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q62639
Elsewhere: RCSB PDB 2L0X · PDBe 2L0X · UniProt Q62639

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.