Research workbench
Solution structure of ilk-pinch complex
Analyse Solution structure of ilk-pinch complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2KBX
- Type
- protein
- Length
- 241 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Integrin-linked protein kinase; Lim and senescent cell antigen-like-containing domain…
- EC
- 2.7.11.1
- UniProt
- Q13418, P48059
- Ligands
- ZN
- Pockets
- 4 · best druggability 0.70
Structure
solution nmr · 2 distinct chains · 38% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Integrin-linked protein kinase (EC 2.7.11.1) | protein | 171 | 47% helix, 0% strand | Q13418 |
| B | Lim and senescent cell antigen-like-containing domain protein 1 | protein | 70 | 16% helix, 23% strand | P48059 |
Ligands and binding sites
- ZN · Zinc ion · metal · 2 copies · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 101 | 0.70 | 0.92 | 29 | empty |
| 2 | 194 | 0.63 | 0.83 | 26 | empty |
| 3 | 247 | 0.61 | 0.80 | 25 | empty |
| 4 | 150 | 0.57 | 0.82 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 709 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 2KBX · Solution structure of ILK-PINCH complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q13418 · AlphaFold monomer V2.0 prediction for integrin-linked protein kinase (Q13418) · a predicted model of the same protein · chain A against A, TM-score 0.71
- P48059 · AlphaFold monomer V2.0 prediction for lim and senescent cell antigen- like-containing… · a predicted model of the same protein · chain B against A, TM-score 0.65
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q13418
- Every structure of UniProt P48059
- Elsewhere: RCSB PDB 2KBX · PDBe 2KBX · UniProt Q13418 · UniProt P48059
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