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Solution structure of cardiac N-domain troponin C mutant F77W-V82A

Analyse Solution structure of cardiac N-domain troponin C mutant F77W-V82A in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2JXL
Type: protein
Length: 89 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Troponin C, slow skeletal and cardiac muscles
UniProt: P63316
Ligands: CA
Pockets: 2 · best druggability 0.52

Structure

solution nmr · 1 distinct chain · 63% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Troponin C, slow skeletal and cardiac muscles	protein	89	63% helix, 4% strand	P63316

Ligands and binding sites

CA · Calcium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	156	0.52	0.78	20	empty
2	93	0.38	0.76	17	empty

Compared structures

2JXL · Solution structure of cardiac N-domain troponin C mutant F77W-V82A · the same entry in another collection · chain A against A, TM-score 1.00
P63316 · AlphaFold monomer V2.0 prediction for troponin C, slow skeletal and cardiac muscles… · a predicted model of the same protein · chain A against A, TM-score 0.88

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P63316
Elsewhere: RCSB PDB 2JXL · PDBe 2JXL · UniProt P63316

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