Research workbench
S45A mutant of streptavidin in complex with biotin
Analyse S45A mutant of streptavidin in complex with biotin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1DF8
- Type
- protein
- Length
- 238 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein (streptavidin)
- UniProt
- P22629
- Ligands
- BTN
- Pockets
- 2 · best druggability 0.51
Structure
x-ray diffraction · 2 distinct chains · 5% helix, 57% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein (streptavidin) | protein | 118 | 5% helix, 58% strand | P22629 |
| B | Protein (streptavidin) | protein | 120 | 5% helix, 56% strand | P22629 |
Ligands and binding sites
- BTN · Biotin · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 98 | 0.51 | 0.82 | 20 | BTN |
| 2 | 90 | 0.49 | 0.82 | 19 | BTN |
Interfaces
1 interface between chains.
- A–B · 1635 Ų buried · 25 hydrogen bonds · protein-protein
Compared structures
- 1DF8 · S45A mutant of streptavidin in complex with biotin · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P22629
- Elsewhere: RCSB PDB 1DF8 · PDBe 1DF8 · UniProt P22629
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