Research workbench
NMR structure of chaperone CHZ1 complexed with histone H2A.Z-H2B
Analyse NMR structure of chaperone CHZ1 complexed with histone H2A.Z-H2B in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2JSS
- Type
- protein
- Length
- 254 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chimera of histone H2B.1 and histone H2A.Z; Uncharacterized protein YER030W
- UniProt
- P02293, Q12692, P40019
- Pockets
- 3 · best druggability 0.52
Structure
solution nmr · 2 distinct chains · 57% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Chimera of histone H2B.1 and histone H2A.Z | protein | 192 | 65% helix, 0% strand | P02293, Q12692 |
| B | Uncharacterized protein YER030W | protein | 62 | 34% helix, 0% strand | P40019 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 72 | 0.52 | 0.85 | 19 | empty |
| 2 | 86 | 0.37 | 0.76 | 19 | empty |
| 3 | 85 | 0.32 | 0.73 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1939 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
- 2JSS · NMR structure of chaperone Chz1 complexed with histone H2A.Z-H2B · the same entry in another collection · chain A against A, TM-score 1.00
- Q12692 · AlphaFold monomer V2.0 prediction for histone H2A.Z (Q12692) · a predicted model of the same protein · chain A against A, TM-score 0.45
- P02293 · AlphaFold monomer V2.0 prediction for histone H2B.1 (P02293) · a predicted model of the same protein · chain A against A, TM-score 0.45
- P40019 · AlphaFold monomer V2.0 prediction for histone H2A.Z-specific chaperone CHZ1 (P40019) · a predicted model of the same protein · chain B against A, TM-score 0.29
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02293
- Every structure of UniProt Q12692
- Every structure of UniProt P40019
- Elsewhere: RCSB PDB 2JSS · PDBe 2JSS · UniProt P02293 · UniProt Q12692 · UniProt P40019
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.