Research workbench
Crystal structure of phospho-CDK2 in complex with cyclin B
Analyse Crystal structure of phospho-CDK2 in complex with cyclin B in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2JGZ
- Type
- protein
- Length
- 549 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cell division protein kinase 2; G2/MITOTIC-specific cyclin-B1
- EC
- 2.7.1.-
- UniProt
- P24941, P14635
- Pockets
- 10 · best druggability 0.77
Structure
x-ray diffraction · 2 distinct chains · 48% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cell division protein kinase 2 (EC 2.7.1.-) | protein | 289 | 34% helix, 18% strand | P24941 |
| B | G2/MITOTIC-specific cyclin-B1 | protein | 260 | 64% helix, 0% strand | P14635 |
Pockets
10 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 90 | 0.77 | 0.98 | 20 | empty |
| 2 | 54 | 0.66 | 0.95 | 24 | empty |
| 3 | 206 | 0.63 | 0.83 | 23 | empty |
| 4 | 251 | 0.56 | 0.77 | 41 | empty |
| 5 | 84 | 0.49 | 0.83 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 1587 Ų buried · 22 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (phosphorylation).
Compared structures
- 2JGZ · Crystal structure of phospho-CDK2 in complex with Cyclin B · the same entry in another collection · chain A against A, TM-score 1.00
- P14635 · AlphaFold monomer V2.0 prediction for G2/MITOTIC-specific cyclin-B1 (P14635) · a predicted model of the same protein · chain B against A, TM-score 0.99
- P24941 · AlphaFold monomer V2.0 prediction for cyclin-dependent kinase 2 (P24941) · a predicted model of the same protein · chain A against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P24941
- Every structure of UniProt P14635
- Elsewhere: RCSB PDB 2JGZ · PDBe 2JGZ · UniProt P24941 · UniProt P14635
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