Research workbench

Human fibrillarin

Analyse Human fibrillarin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2IPX
Type: protein
Length: 220 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RRNA 2'-O-methyltransferase fibrillarin
EC: 2.1.1.-
UniProt: P22087
Ligands: MTA, CA
Pockets: 1 · best druggability 0.44

Structure

x-ray diffraction · 1 distinct chain · 30% helix, 30% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RRNA 2'-O-methyltransferase fibrillarin (EC 2.1.1.-)	protein	220	30% helix, 30% strand	P22087

Ligands and binding sites

MTA · 5'-deoxy-5'-methylthioadenosine · ligand · chains A
CA · Calcium ion · metal · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	86	0.44	0.80	25	MTA

Modifications

Observed in the structure: 5 modified (engineered).

Compared structures

2IPX · Human Fibrillarin · the same entry in another collection · chain A against A, TM-score 1.00
P22087 · AlphaFold monomer V2.0 prediction for rRNA 2'-O-methyltransferase fibrillarin (P22087) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P22087
Elsewhere: RCSB PDB 2IPX · PDBe 2IPX · UniProt P22087

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.