UniProt P22087
rRNA 2'-O-methyltransferase fibrillarin (P22087)
rRNA 2'-O-methyltransferase fibrillarin (UniProt P22087), EC 2.1.1.-: 14 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 10 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P22087
- Protein
- rRNA 2'-O-methyltransferase fibrillarin
- EC
- 2.1.1.-
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 10 · 3 records with a druggable one
Structures
15 records of P22087 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2IPX | Human Fibrillarin | x-ray diffraction | A | — | — |
| 2IPX | Human fibrillarin | x-ray diffraction | A | — | — |
| 7MQA | Cryo-EM structure of the human SSU processome, state post-A1 | electron microscopy | SC, SD | — | 2 (best 0.87) |
| 7SE6 | Crystal structure of human fibrillarin in ligand-free state | x-ray diffraction | A | — | — |
| 7SE7 | Crystal structure of human fibrillarin in complex with S-adenosyl-L- methionine | x-ray diffraction | A | — | — |
| 7SE8 | Crystal structure of human fibrillarin in complex with fragment 1 from cocktail soak | x-ray diffraction | A, B | 8W1 | — |
| 7SE9 | Crystal structure of human Fibrillarin in complex with compound 1 from single soak | x-ray diffraction | A, B | 8W1 | 4 (best 0.56) |
| 7SE9 | Crystal structure of human fibrillarin in complex with compound 1 from single soak | x-ray diffraction | A, B | 8W1 | — |
| 7SEA | Crystal structure of human fibrillarin in complex with compound 2 from cocktail soak | x-ray diffraction | A | 8XF | — |
| 7SEB | Crystal structure of human fibrillarin in complex with compound 2 from single soak | x-ray diffraction | A | 8XF | — |
| 7SEC | Crystal structure of human Fibrillarin in complex with compound 1a | x-ray diffraction | A, B | 8WP | 3 (best 0.59) |
| 7SEC | Crystal structure of human fibrillarin in complex with compound 1A | x-ray diffraction | A, B | 8WP | — |
| 7SED | Crystal structure of human Fibrillarin in complex with compound 2a | x-ray diffraction | A | 8VD | 1 (best 0.48) |
| 7SED | Crystal structure of human fibrillarin in complex with compound 2A | x-ray diffraction | A | 8VD | — |
| P22087 | AlphaFold monomer V2.0 prediction for rRNA 2'-O-methyltransferase fibrillarin (P22087) | predicted | A | — | — |
Ligands
- 8W1 · (5S)-3-methyl-7-(trifluoromethyl)pyrrolo[1,2-a]pyrazin-1(2H)-one · in 3 records
- 8VD · N-(piperidin-4-yl)-6-(trifluoromethyl)pyrimidin-4-amine · in 2 records
- 8WP · 2-[(8S)-4-oxo-2-(trifluoromethyl)-4,5-dihydropyrazolo[1,5-a]pyrazin-6-yl]acetamide · in 2 records
- 8XF · 6-(trifluoromethyl)pyrimidin-4-amine · in 2 records
Experiment against prediction
- 2IPX chain A against the predicted model P22087: TM-score 0.99, RMSD 0.53 Å
- 2IPX chain A against the predicted model P22087: TM-score 0.99, RMSD 0.53 Å
- 7MQA chain SC against the predicted model P22087: TM-score 0.98, RMSD 0.77 Å
- 7SED chain A against the predicted model P22087: TM-score 0.98, RMSD 1.29 Å
- 7SED chain A against the predicted model P22087: TM-score 0.98, RMSD 1.29 Å
- 7SEA chain A against the predicted model P22087: TM-score 0.98, RMSD 1.38 Å
- 7MQA chain SD against the predicted model P22087: TM-score 0.98, RMSD 0.96 Å
- 7SEB chain A against the predicted model P22087: TM-score 0.97, RMSD 1.38 Å
- 7SE6 chain A against the predicted model P22087: TM-score 0.97, RMSD 1.38 Å
- 7SEC chain B against the predicted model P22087: TM-score 0.97, RMSD 1.13 Å
Elsewhere
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