MolNFT v1 · #187428 · protein

Crystal structure of human fibrillarin in complex with S-adenosyl-L- methionine

7SE7 · RRNA 2'-O-methyltransferase fibrillarin: “Crystal structure of human fibrillarin in complex with S-adenosyl-L- methionine”. X-ray diffraction, 1 ligand (SAM), 1 pocket (best druggability 0.46). MolNFT v1 #187428 on GenesisL1: 3D…

PDB: 7SE7
Type: protein
Length: 229 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RRNA 2'-O-methyltransferase fibrillarin
EC: 2.1.1.-
UniProt: P22087
Ligands: SAM
Pockets: 1 · best druggability 0.46

Structure

x-ray diffraction · 1 distinct chain · 29% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RRNA 2'-O-methyltransferase fibrillarin (EC 2.1.1.-)	protein	229	29% helix, 31% strand	P22087

Ligands and binding sites

SAM · S-adenosylmethionine · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	112	0.46	0.79	25	SAM

Compared structures

7SE7 · Crystal structure of human Fibrillarin in complex with S-adenosyl-L-methionine · the same entry in another collection · chain A against A, TM-score 1.00
P22087 · AlphaFold monomer V2.0 prediction for rRNA 2'-O-methyltransferase fibrillarin (P22087) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P22087
Elsewhere: RCSB PDB 7SE7 · PDBe 7SE7 · UniProt P22087

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.