Research workbench
Solution structure of the talin F3 domain in complex with a chimeric BETA3 integrin-pip kinase peptide- minimized average structure
Analyse Solution structure of the talin F3 domain in complex with a chimeric BETA3… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2H7E
- Type
- protein
- Length
- 135 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Talin-1; Chimera of 24-mer peptide from integrin beta-3 and 10-mer peptide from…
- UniProt
- P54939, P05106, O70161
- Pockets
- 1 · best druggability 0.30
Structure
solution nmr · 2 distinct chains · 23% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Talin-1 | protein | 101 | 18% helix, 44% strand | P54939 |
| B | Chimera of 24-mer peptide from integrin beta-3 and 10-mer peptide from phosphatidylinositol-4-phosphate 5-kinase type-1 gamma | protein | 34 | 38% helix, 9% strand | P05106, O70161 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 79 | 0.30 | 0.73 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 1073 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (phosphorylation).
Compared structures
- 2H7E · Solution structure of the talin F3 domain in complex with a chimeric beta3 integrin-PIP… · the same entry in another collection · chain A against A, TM-score 1.00
- P54939 · AlphaFold monomer V2.0 prediction for talin-1 (P54939) · a predicted model of the same protein · chain A against A, TM-score 0.90
- O70161 · AlphaFold monomer V2.0 prediction for phosphatidylinositol 4-phosphate 5-kinase type-1… · a predicted model of the same protein · chain B against A, TM-score 0.50
- P05106 · AlphaFold monomer V2.0 prediction for integrin beta-3 (P05106) · a predicted model of the same protein · chain B against A, TM-score 0.46
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P54939
- Every structure of UniProt P05106
- Every structure of UniProt O70161
- Elsewhere: RCSB PDB 2H7E · PDBe 2H7E · UniProt P54939 · UniProt P05106 · UniProt O70161
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