UniProt O70161
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (O70161)
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (UniProt O70161): 6 experimental structures and 1 predicted model on GenesisL1, 9 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O70161
- Protein
- Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
- Experimental structures
- 6
- Predicted models
- 1
- Pockets
- 9 · 1 record with a druggable one
Structures
7 records of O70161 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1Y19 | Structural basis for phosphatidylinositol phosphate kinase type I-gamma binding to talin at focal… | x-ray diffraction | A, C, E, G, I, K | — | — |
| 1Y19 | Structural basis for phosphatidylinositol phosphate kinase type I- gamma binding to talin at focal… | x-ray diffraction | A, C, E, G, I, K | — | — |
| 2H7D | Solution structure of the talin F3 domain in complex with a chimeric beta3 integrin-PIP kinase… | solution nmr | B | — | — |
| 2H7D | Solution structure of the talin F3 domain in complex with a chimeric BETA3 integrin-pip kinase… | solution nmr | B | — | — |
| 2H7E | Solution structure of the talin F3 domain in complex with a chimeric beta3 integrin-PIP kinase… | solution nmr | B | — | — |
| 2H7E | Solution structure of the talin F3 domain in complex with a chimeric BETA3 integrin-pip kinase… | solution nmr | B | — | — |
| O70161 | AlphaFold monomer V2.0 prediction for phosphatidylinositol 4-phosphate 5-kinase type-1 gamma… | predicted | A | — | 9 (best 0.78) |
Experiment against prediction
- 2H7D chain B against the predicted model O70161: TM-score 0.51, RMSD 2.68 Å
- 2H7D chain B against the predicted model O70161: TM-score 0.51, RMSD 2.68 Å
- 2H7E chain B against the predicted model O70161: TM-score 0.50, RMSD 2.16 Å
- 2H7E chain B against the predicted model O70161: TM-score 0.50, RMSD 2.16 Å
- 2H7D chain B against the predicted model P05106: TM-score 0.47, RMSD 2.36 Å
- 2H7D chain B against the predicted model P05106: TM-score 0.47, RMSD 2.36 Å
- 2H7E chain B against the predicted model P05106: TM-score 0.46, RMSD 1.96 Å
- 2H7E chain B against the predicted model P05106: TM-score 0.46, RMSD 1.96 Å
- 1Y19 chain A against the predicted model O70161: TM-score 0.39, RMSD 0.63 Å
- 1Y19 chain A against the predicted model O70161: TM-score 0.39, RMSD 0.63 Å
Elsewhere
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