MolNFT v1 · #38731 · protein
Solution structure of the talin F3 domain in complex with a chimeric BETA3 integrin-pip kinase peptide
2H7D · Talin-1: “Solution structure of the talin F3 domain in complex with a chimeric BETA3 integrin-pip kinase peptide”. Solution nmr. MolNFT v1 #38731 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2H7D
- Type
- protein
- Length
- 135 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Talin-1; Chimera of 24-mer peptide from integrin beta-3 and 10-mer peptide from…
- UniProt
- P54939, P05106, O70161
Structure
solution nmr · 2 distinct chains · 24% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Talin-1 | protein | 101 | 18% helix, 44% strand | P54939 |
| B | Chimera of 24-mer peptide from integrin beta-3 and 10-mer peptide from phosphatidylinositol-4-phosphate 5-kinase type-1 gamma | protein | 34 | 41% helix, 9% strand | P05106, O70161 |
Interfaces
1 interface between chains.
- A–B · 1101 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (phosphorylation).
Compared structures
- 2H7D · Solution structure of the talin F3 domain in complex with a chimeric beta3 integrin-PIP… · the same entry in another collection · chain A against A, TM-score 1.00
- P54939 · AlphaFold monomer V2.0 prediction for talin-1 (P54939) · a predicted model of the same protein · chain A against A, TM-score 0.89
- O70161 · AlphaFold monomer V2.0 prediction for phosphatidylinositol 4-phosphate 5-kinase type-1… · a predicted model of the same protein · chain B against A, TM-score 0.51
- P05106 · AlphaFold monomer V2.0 prediction for integrin beta-3 (P05106) · a predicted model of the same protein · chain B against A, TM-score 0.47
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P54939
- Every structure of UniProt P05106
- Every structure of UniProt O70161
- Elsewhere: RCSB PDB 2H7D · PDBe 2H7D · UniProt P54939 · UniProt P05106 · UniProt O70161
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