Research workbench
Angiopoietin-2/TIE2 complex crystal structure
Analyse Angiopoietin-2/TIE2 complex crystal structure in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2GY7
- Type
- protein
- Length
- 639 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Angiopoietin-2; Angiopoietin-1 receptor
- EC
- 2.7.10.1
- UniProt
- O15123, Q02763
- Ligands
- NAG, NDG, CA, SO4
- Pockets
- 7 · best druggability 0.69
Structure
x-ray diffraction · 2 distinct chains · 7% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Angiopoietin-2 | protein | 216 | 14% helix, 25% strand | O15123 |
| B | Angiopoietin-1 receptor (EC 2.7.10.1) | protein | 423 | 3% helix, 37% strand | Q02763 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 8 copies · chains B
- NDG · 2-acetamido-2-deoxy-alpha-D-glucopyranose · sugar
- CA · Calcium ion · metal · chains A
- SO4 · Sulfate ion · ion · 2 copies · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 532 | 0.69 | 0.79 | 60 | SO4 |
| 2 | 262 | 0.58 | 0.78 | 34 | empty |
| 3 | 212 | 0.58 | 0.80 | 39 | empty |
| 4 | 226 | 0.56 | 0.78 | 24 | empty |
| 5 | 62 | 0.41 | 0.81 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 566 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 17 disulfide, 3 glycan (disulfide, N-glycosylation).
Compared structures
- 2GY7 · Angiopoietin-2/Tie2 Complex Crystal Structure · the same entry in another collection · chain A against A, TM-score 1.00
- Q02763 · AlphaFold monomer V2.0 prediction for angiopoietin-1 receptor (Q02763) · a predicted model of the same protein · chain B against A, TM-score 0.99
- O15123 · AlphaFold monomer V2.0 prediction for angiopoietin-2 (O15123) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O15123
- Every structure of UniProt Q02763
- Elsewhere: RCSB PDB 2GY7 · PDBe 2GY7 · UniProt O15123 · UniProt Q02763
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