UniProt Q02763
Angiopoietin-1 receptor (Q02763)
Angiopoietin-1 receptor (UniProt Q02763), EC 2.7.10.1: 29 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 17 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q02763
- Protein
- Angiopoietin-1 receptor
- EC
- 2.7.10.1
- Experimental structures
- 29
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 17 · 3 records with a druggable one
Structures
30 records of Q02763 in the MolNFT archive: 29 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1FVR | TIE2 kinase domain | x-ray diffraction | A, B | — | — |
| 1FVR | TIE2 kinase domain | x-ray diffraction | A, B | — | — |
| 2GY5 | Tie2 Ligand-Binding Domain Crystal Structure | x-ray diffraction | A | — | — |
| 2GY5 | TIE2 ligand-binding domain crystal structure | x-ray diffraction | A | — | — |
| 2GY7 | Angiopoietin-2/Tie2 Complex Crystal Structure | x-ray diffraction | B | — | — |
| 2GY7 | Angiopoietin-2/TIE2 complex crystal structure | x-ray diffraction | B | — | — |
| 2OO8 | Synthesis, Structural Analysis, and SAR Studies of Triazine Derivatives as Potent, Selective Tie-2… | x-ray diffraction | X | — | — |
| 2OO8 | Synthesis, structural analysis, and sar studies of triazine derivatives as potent, selective tie-2… | x-ray diffraction | X | — | — |
| 2OSC | Synthesis, Structural Analysis, and SAR Studies of Triazine Derivatives as Potent, Selective Tie-2… | x-ray diffraction | A | — | — |
| 2OSC | Synthesis, structural analysis, and sar studies of triazine derivatives as potent, selective tie-2… | x-ray diffraction | A | — | — |
| 2P4I | Evolution of a highly Selective and Potent 2-(Pyridin-2-yl)-1,3,5-triazine Tie-2 Kinase Inhibitor | x-ray diffraction | A, B | — | — |
| 2P4I | Evolution of a highly selective and potent 2-(pyridin-2-yl)- 1,3,5-triazine tie-2 kinase inhibitor | x-ray diffraction | A, B | — | — |
| 2WQB | Structure of the Tie2 kinase domain in complex with a thiazolopyrimidine inhibitor | x-ray diffraction | A | — | — |
| 2WQB | Structure of the TIE2 kinase domain in complex with a thiazolopyrimidine inhibitor | x-ray diffraction | A | — | — |
| 3BEA | cFMS tyrosine kinase (tie2 KID) in complex with a pyrimidinopyridone inhibitor | x-ray diffraction | A | — | — |
| 3BEA | Cfms tyrosine kinase (TIE2 kid) in complex with a pyrimidinopyridone inhibitor | x-ray diffraction | A | — | — |
| 3L8P | Crystal structure of cytoplasmic kinase domain of Tie2 complexed with inhibitor CEP11207 | x-ray diffraction | A | — | — |
| 3L8P | Crystal structure of cytoplasmic kinase domain of TIE2 complexed with inhibitor CEP11207 | x-ray diffraction | A | — | — |
| 4X3J | Selection of fragments for kinase inhibitor design: decoration is key | x-ray diffraction | A | 3WR | 2 (best 0.57) |
| 4X3J | Selection of fragments for kinase inhibitor design: decoration is key | x-ray diffraction | A | — | — |
| 5MYA | Homodimerization of TIE2 fibronectin-like domains 1-3 in space group C2 | x-ray diffraction | A, B | NAG | — |
| 5MYB | Homodimerization of Tie2 Fibronectin-like domains 2 and 3 in space group P21 | x-ray diffraction | A, B | NAG | — |
| 5MYB | Homodimerization of TIE2 fibronectin-like domains 2 and 3 in space group P21 | x-ray diffraction | A, B | NAG | — |
| 5UTK | Crystal structure of the membrane proximal three fibronectin type III (FNIII) domains of Tie2… | x-ray diffraction | A, B | — | 4 (best 0.52) |
| 5UTK | Crystal structure of the membrane proximal three fibronectin type III (fniii) domains of TIE2… | x-ray diffraction | A, B | — | — |
| 6MWE | Crystal structure of TIE2 in complex with decipera compound DP1919 | x-ray diffraction | A, B | SO4, 919 | — |
| 6MWE | Crystal structure of TIE2 in complex with decipera compound DP1919 | x-ray diffraction | A, B | SO4, 919 | — |
| 7E72 | Crystal structure of Tie2-agonistic antibody in complex with human Tie2 Fn2-3 | x-ray diffraction | E, F | — | — |
| 7E72 | Crystal structure of TIE2-agonistic antibody in complex with human TIE2 FN2-3 | x-ray diffraction | E, F | — | — |
| Q02763 | AlphaFold monomer V2.0 prediction for angiopoietin-1 receptor (Q02763) | predicted | A | — | 11 (best 0.74) |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 3 records
- 919 · 4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide · in 2 records
- SO4 · Sulfate ion · in 2 records
- 3WR · 1-[4-(4-amino-5-oxopyrido[2,3-d]pyrimidin-8(5H)-yl)phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea · in 1 record
Experiment against prediction
- 2GY7 chain B against the predicted model Q02763: TM-score 0.99, RMSD 0.60 Å
- 2GY7 chain B against the predicted model Q02763: TM-score 0.99, RMSD 0.60 Å
- 2GY5 chain A against the predicted model Q02763: TM-score 0.99, RMSD 0.64 Å
- 2GY5 chain A against the predicted model Q02763: TM-score 0.99, RMSD 0.64 Å
- 4X3J chain A against the predicted model Q02763: TM-score 0.97, RMSD 1.11 Å
- 4X3J chain A against the predicted model Q02763: TM-score 0.97, RMSD 1.11 Å
- 2OSC chain A against the predicted model Q02763: TM-score 0.96, RMSD 1.50 Å
- 2OSC chain A against the predicted model Q02763: TM-score 0.96, RMSD 1.50 Å
- 2OO8 chain X against the predicted model Q02763: TM-score 0.96, RMSD 1.66 Å
- 2OO8 chain X against the predicted model Q02763: TM-score 0.96, RMSD 1.66 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.