Research workbench
Estrogen related receptor-gamma ligand binding domain
Analyse Estrogen related receptor-gamma ligand binding domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2GP7
- Type
- protein
- Length
- 897 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Estrogen-related receptor gamma
- UniProt
- P62508
- Ligands
- CA
- Pockets
- 13 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 68% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, D | Estrogen-related receptor gamma | protein | 224 | 68% helix, 3% strand | P62508 |
| B | Estrogen-related receptor gamma | protein | 225 | 67% helix, 3% strand | P62508 |
Ligands and binding sites
- CA · Calcium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
13 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1147 | 0.78 | 0.80 | 109 | empty |
| 2 | 61 | 0.74 | 0.98 | 16 | empty |
| 3 | 576 | 0.70 | 0.79 | 56 | empty |
| 4 | 154 | 0.68 | 0.88 | 34 | empty |
| 5 | 453 | 0.67 | 0.79 | 53 | empty |
Interfaces
6 interfaces between chains.
- C–D · 1480 Ų buried · 16 hydrogen bonds · protein-protein
- A–B · 1417 Ų buried · 15 hydrogen bonds · protein-protein
- B–C · 321 Ų buried · 2 hydrogen bonds · protein-protein
- A–D · 321 Ų buried · 4 hydrogen bonds · protein-protein
- B–D · 108 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62508
- Elsewhere: RCSB PDB 2GP7 · PDBe 2GP7 · UniProt P62508
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