Structure of a complex between the pair of the LDL receptor ligand- binding modules 3-4 and the receptor associated protein (rap).

Structure

x-ray diffraction · 2 distinct chains · 58% helix, 7% strand (DSSP).

Ligands and binding sites

• NA · Sodium ion · metal · 4 copies · chains A, B
• CA · Calcium ion · metal · 2 copies · chains A, B
• MPD · (4S)-2-methyl-2,4-pentanediol · additive · 5 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 754 Ų buried · 20 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

• 2FCW · Structure of a Complex Between the Pair of the LDL Receptor Ligand-Binding Modules 3-4… · the same entry in another collection · chain A against A, TM-score 1.00
• P30533 · AlphaFold monomer V2.0 prediction for alpha-2-macroglobulin receptor- associated protein… · a predicted model of the same protein · chain A against A, TM-score 0.96
• P01130 · AlphaFold monomer V2.0 prediction for low-density lipoprotein receptor (P01130) · a predicted model of the same protein · chain B against A, TM-score 0.58

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P30533
• Every structure of UniProt P01130
• Elsewhere: RCSB PDB 2FCW · PDBe 2FCW · UniProt P30533 · UniProt P01130