Research workbench
Crystal structure of human fpps in complex with alendronate
Analyse Crystal structure of human fpps in complex with alendronate in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2F92
- Type
- protein
- Length
- 343 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Farnesyl diphosphate synthase
- EC
- 2.5.1.1, 2.5.1.10
- UniProt
- P14324
- Ligands
- AHD, ZN, PO4
- Pockets
- 2 · best druggability 0.78
Structure
x-ray diffraction · 1 distinct chain · 76% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| F | Farnesyl diphosphate synthase (EC 2.5.1.1, 2.5.1.10) | protein | 343 | 76% helix, 1% strand | P14324 |
Ligands and binding sites
- AHD · 4-amino-1-hydroxybutane-1,1-diyldiphosphonate · ligand · chains F
- ZN · Zinc ion · metal · 3 copies · chains F
- PO4 · Phosphate ion · ion · chains F
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 420 | 0.78 | 0.87 | 58 | ZN, PO4, AHD |
| 2 | 53 | 0.28 | 0.74 | 16 | empty |
Compared structures
- 2F92 · Crystal structure of human FPPS in complex with alendronate · the same entry in another collection · chain F against F, TM-score 1.00
- P14324 · AlphaFold monomer V2.0 prediction for farnesyl pyrophosphate synthase (P14324) · a predicted model of the same protein · chain F against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P14324
- Elsewhere: RCSB PDB 2F92 · PDBe 2F92 · UniProt P14324
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