Research workbench
Membrane-bound glutamate carboxypeptidase II (gcpii) with bound glutamate
Analyse Membrane-bound glutamate carboxypeptidase II (gcpii) with bound glutamate in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2C6G
- Type
- protein
- Length
- 679 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamate carboxypeptidase II
- EC
- 3.4.17.21
- UniProt
- Q04609
- Ligands
- GLU, NAG, BMA, MAN, ZN, CA, CL
- Pockets
- 7 · best druggability 0.72
Structure
x-ray diffraction · 1 distinct chain · 39% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glutamate carboxypeptidase II (EC 3.4.17.21) | protein | 679 | 39% helix, 19% strand | Q04609 |
Ligands and binding sites
- GLU · Glutamic acid · ligand · chains A
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 9 copies · chains A
- BMA · beta-D-mannopyranose · sugar
- MAN · alpha-D-mannopyranose · sugar
- ZN · Zinc ion · metal · 2 copies · chains A
- CA · Calcium ion · metal · chains A
- CL · Chloride ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 416 | 0.72 | 0.83 | 58 | GLU, CL |
| 2 | 321 | 0.55 | 0.75 | 53 | empty |
| 3 | 185 | 0.48 | 0.75 | 19 | empty |
| 4 | 116 | 0.42 | 0.76 | 26 | empty |
| 5 | 86 | 0.32 | 0.73 | 20 | empty |
Modifications
Observed in the structure: 6 glycan (N-glycosylation).
Compared structures
- 2C6G · Membrane-bound glutamate carboxypeptidase II (GCPII) with bound glutamate · the same entry in another collection · chain A against A, TM-score 1.00
- Q04609 · AlphaFold monomer V2.0 prediction for glutamate carboxypeptidase 2 (Q04609) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q04609
- Elsewhere: RCSB PDB 2C6G · PDBe 2C6G · UniProt Q04609
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