Research workbench

Photosynthetic reaction center mutant with gly M203 replaced with leu

Analyse Photosynthetic reaction center mutant with gly M203 replaced with leu in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2BOZ
Type: protein
Length: 823 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Reaction center protein H chain; Reaction center protein L chain; Reaction center protein…
UniProt: P11846, P02954, P02953
Ligands: BCL, D10, BPH, U10, SPN, FE, PO4
Pockets: 11 · best druggability 0.82

Structure

x-ray diffraction · 3 distinct chains · 52% helix, 9% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
H	Reaction center protein H chain	protein	240	25% helix, 25% strand	P11846
L	Reaction center protein L chain	protein	281	63% helix, 3% strand	P02954
M	Reaction center protein M chain	protein	302	64% helix, 3% strand	P02953

Ligands and binding sites

BCL · Bacteriochlorophyll A · ligand · 4 copies · chains L, M
D10 · Decane · ligand · 3 copies · chains H
BPH · Bacteriopheophytin A · ligand · 2 copies · chains L, M
U10 · Ubiquinone-10 · ligand · 2 copies · chains L, M
SPN · Speroidenone · ligand · chains M
FE · Fe (III) ion · metal · chains L, M
PO4 · Phosphate ion · ion · 2 copies · chains L, M
LDA · Lauryl dimethylamine-N-oxide · additive · 4 copies · chains H, M, L

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

11 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	855	0.82	0.84	70	BCL
2	137	0.78	0.96	33	empty
3	142	0.71	0.90	28	U10
4	147	0.59	0.83	24	U10
5	97	0.58	0.86	18	SPN

Interfaces

3 interfaces between chains.

L–M · 4529 Å² buried · 70 hydrogen bonds · protein-protein
H–M · 2858 Å² buried · 48 hydrogen bonds · protein-protein
H–L · 1619 Å² buried · 16 hydrogen bonds · protein-protein

Compared structures

2BOZ · Photosynthetic Reaction Center Mutant With Gly M203 Replaced With Leu · the same entry in another collection · chain H against H, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P11846
Every structure of UniProt P02954
Every structure of UniProt P02953
Elsewhere: RCSB PDB 2BOZ · PDBe 2BOZ · UniProt P11846 · UniProt P02954 · UniProt P02953

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.