Research workbench
Solution structure of mouse SOCS3 in complex with a phosphopeptide from the GP130 receptor
Analyse Solution structure of mouse SOCS3 in complex with a phosphopeptide from the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2BBU
- Type
- protein
- Length
- 171 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Suppressor of cytokine signaling 3; GP130 phosphopeptide
- UniProt
- O35718
- Pockets
- 1 · best druggability 0.63
Structure
solution nmr · 2 distinct chains · 19% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Suppressor of cytokine signaling 3 | protein | 156 | 21% helix, 15% strand | O35718 |
| B | GP130 phosphopeptide | protein | 15 | 0% helix, 0% strand | — |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 343 | 0.63 | 0.78 | 47 | empty |
Interfaces
1 interface between chains.
- A–B · 622 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (phosphorylation).
Compared structures
- 2BBU · solution structure of mouse socs3 in complex with a phosphopeptide from the gp130 receptor · the same entry in another collection · chain A against A, TM-score 1.00
- O35718 · AlphaFold monomer V2.0 prediction for suppressor of cytokine signaling 3 (O35718) · a predicted model of the same protein · chain A against A, TM-score 0.58
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O35718
- Elsewhere: RCSB PDB 2BBU · PDBe 2BBU · UniProt O35718
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