MolNFT v1 · #432180 · protein
AlphaFold monomer V2.0 prediction for suppressor of cytokine signaling 3 (O35718)
O35718: “AlphaFold monomer V2.0 prediction for suppressor of cytokine signaling 3 (O35718)”. 3 pockets (best druggability 0.51). MolNFT v1 #432180 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- O35718
- Type
- protein
- Length
- 225 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x80D2ac0F5e3268bC5C1d28BBAA07E3169BB02b79
- Molecule
- Suppressor of cytokine signaling 3
- UniProt
- O35718
- Pockets
- 3 · best druggability 0.51
Structure
1 distinct chain · 28% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Suppressor of cytokine signaling 3 | protein | 225 | 28% helix, 18% strand | O35718 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 119 | 0.51 | 0.81 | 21 | empty |
| 2 | 137 | 0.43 | 0.76 | 18 | empty |
| 3 | 122 | 0.38 | 0.74 | 21 | empty |
Compared structures
- 4GL9 · Crystal structure of inhibitory protein SOCS3 in complex with JAK2 kinase domain and… · an experimental structure of the same protein · chain A against F, TM-score 0.54
- 4GL9 · Crystal structure of inhibitory protein SOCS3 in complex with JAK2 kinase domain and… · an experimental structure of the same protein · chain A against F, TM-score 0.54
- 2HMH · Crystal structure of SOCS3 in complex with gp130(pTyr757) phosphopeptide. · an experimental structure of the same protein · chain A against A, TM-score 0.49
- 2HMH · Crystal structure of SOCS3 in complex with GP130(PTYR757) phosphopeptide. · an experimental structure of the same protein · chain A against A, TM-score 0.49
- 2BBU · solution structure of mouse socs3 in complex with a phosphopeptide from the gp130 receptor · an experimental structure of the same protein · chain A against A, TM-score 0.43
- 2BBU · Solution structure of mouse SOCS3 in complex with a phosphopeptide from the GP130 receptor · an experimental structure of the same protein · chain A against A, TM-score 0.43
- 2JZ3 · Socs box elonginbc ternary complex · an experimental structure of the same protein · chain A against A, TM-score 0.06
- 2JZ3 · SOCS box elonginBC ternary complex · an experimental structure of the same protein · chain A against A, TM-score 0.06
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O35718
- Elsewhere: UniProt O35718 · AlphaFold DB O35718
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