MolNFT v1 · #41809 · protein
Socs box elonginbc ternary complex
2JZ3 · Suppressor of cytokine signaling 3: “Socs box elonginbc ternary complex”. Solution nmr, 1 pocket (best druggability 0.61). MolNFT v1 #41809 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 2JZ3
- Type
- protein
- Length
- 229 residues
- Chains
- 3
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Suppressor of cytokine signaling 3; Transcription elongation factor B polypeptide 2…
- UniProt
- O35718, Q15370, P83940
- Pockets
- 1 · best druggability 0.61
Structure
solution nmr · 3 distinct chains · 28% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Suppressor of cytokine signaling 3 | protein | 15 | 73% helix, 0% strand | O35718 |
| B | Transcription elongation factor B polypeptide 2 | protein | 118 | 13% helix, 21% strand | Q15370 |
| C | Transcription elongation factor B polypeptide 1 | protein | 96 | 41% helix, 16% strand | P83940 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 230 | 0.61 | 0.80 | 33 | empty |
Interfaces
2 interfaces between chains.
- B–C · 908 Ų buried · 12 hydrogen bonds · protein-protein
- A–C · 730 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 2JZ3 · SOCS box elonginBC ternary complex · the same entry in another collection · chain A against A, TM-score 1.00
- P83940 · AlphaFold monomer V2.0 prediction for elongin-C (P83940) · a predicted model of the same protein · chain C against A, TM-score 0.81
- Q15370 · AlphaFold monomer V2.0 prediction for elongin-B (Q15370) · a predicted model of the same protein · chain B against A, TM-score 0.69
- O35718 · AlphaFold monomer V2.0 prediction for suppressor of cytokine signaling 3 (O35718) · a predicted model of the same protein · chain A against A, TM-score 0.44
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O35718
- Every structure of UniProt Q15370
- Every structure of UniProt P83940
- Elsewhere: RCSB PDB 2JZ3 · PDBe 2JZ3 · UniProt O35718 · UniProt Q15370 · UniProt P83940
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