UniProt O35718
Suppressor of cytokine signaling 3 (O35718)
Suppressor of cytokine signaling 3 (UniProt O35718): 8 experimental structures and 1 predicted model on GenesisL1, 3 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O35718
- Protein
- Suppressor of cytokine signaling 3
- Experimental structures
- 8
- Predicted models
- 1
- Pockets
- 3 · 1 record with a druggable one
Structures
9 records of O35718 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2BBU | solution structure of mouse socs3 in complex with a phosphopeptide from the gp130 receptor | solution nmr | A | — | — |
| 2BBU | Solution structure of mouse SOCS3 in complex with a phosphopeptide from the GP130 receptor | solution nmr | A | — | — |
| 2HMH | Crystal structure of SOCS3 in complex with gp130(pTyr757) phosphopeptide. | x-ray diffraction | A | — | — |
| 2HMH | Crystal structure of SOCS3 in complex with GP130(PTYR757) phosphopeptide. | x-ray diffraction | A | — | — |
| 2JZ3 | SOCS box elonginBC ternary complex | solution nmr | A | — | — |
| 2JZ3 | Socs box elonginbc ternary complex | solution nmr | A | — | — |
| 4GL9 | Crystal structure of inhibitory protein SOCS3 in complex with JAK2 kinase domain and fragment of… | x-ray diffraction | E, F, G, H | — | — |
| 4GL9 | Crystal structure of inhibitory protein SOCS3 in complex with JAK2 kinase domain and fragment of… | x-ray diffraction | E, F, G, H | — | — |
| O35718 | AlphaFold monomer V2.0 prediction for suppressor of cytokine signaling 3 (O35718) | predicted | A | — | 3 (best 0.51) |
Experiment against prediction
- 4GL9 chain E against the predicted model O35718: TM-score 0.95, RMSD 1.07 Å
- 4GL9 chain E against the predicted model O35718: TM-score 0.95, RMSD 1.07 Å
- 4GL9 chain G against the predicted model O35718: TM-score 0.95, RMSD 1.07 Å
- 4GL9 chain G against the predicted model O35718: TM-score 0.95, RMSD 1.07 Å
- 4GL9 chain F against the predicted model O35718: TM-score 0.95, RMSD 1.19 Å
- 4GL9 chain F against the predicted model O35718: TM-score 0.95, RMSD 1.19 Å
- 2HMH chain A against the predicted model O35718: TM-score 0.87, RMSD 1.88 Å
- 2HMH chain A against the predicted model O35718: TM-score 0.87, RMSD 1.88 Å
- 2BBU chain A against the predicted model O35718: TM-score 0.58, RMSD 3.36 Å
- 2BBU chain A against the predicted model O35718: TM-score 0.58, RMSD 3.36 Å
Elsewhere
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