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Crystal structure of the androgen receptor ligand binding domain T877A mutant in complex with hydroxyflutamide

Analyse Crystal structure of the androgen receptor ligand binding domain T877A mutant… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2AX6
Type: protein
Length: 242 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Androgen receptor
UniProt: P10275
Ligands: HFT
Pockets: 2 · best druggability 0.81

Structure

x-ray diffraction · 1 distinct chain · 70% helix, 5% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Androgen receptor	protein	242	70% helix, 5% strand	P10275

Ligands and binding sites

HFT · Hydroxyflutamide · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	126	0.81	0.98	22	HFT
2	169	0.65	0.85	26	empty

Compared structures

2AX6 · Crystal Structure Of The Androgen Receptor Ligand Binding Domain T877A Mutant In Complex… · the same entry in another collection · chain A against A, TM-score 1.00
P10275 · AlphaFold monomer V2.0 prediction for androgen receptor (P10275) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P10275
Elsewhere: RCSB PDB 2AX6 · PDBe 2AX6 · UniProt P10275

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