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Ligand · HFT

HFT · Hydroxyflutamide

HFT, Hydroxyflutamide (C11 H11 F3 N2 O4, 292.2 g/mol), in the MolNFT structures on GenesisL1: bound in 16 records (8 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found with it.

Component
HFT
Formula
C11 H11 F3 N2 O4
Class
ligand
Structures
16
PDB entries
8

Binding sites

HFT in 16 structures; the first of them:

  • 2AX6 · Crystal Structure Of The Androgen Receptor Ligand Binding Domain T877A Mutant In Complex… · HFT A1 · binds LEU701, LEU704, ASN705, LEU707, GLY708, GLN711, MET742, MET745 and 10 more
  • 4OGH · Crystal structure of T877A-AR-LBD · HFT A1001 · binds LEU701, LEU704, ASN705, LEU707, GLY708, GLN711, MET742, MET745 and 7 more
  • 4OH5 · Crystal structure of T877A-AR-LBD bound with co-regulator peptide · HFT A1001 · binds LEU701, LEU704, ASN705, LEU707, GLY708, GLN711, MET742, MET745 and 9 more
  • 4OH6 · Crystal structure of T877A-AR-LBD bound with co-regulator peptide · HFT A1001 · binds LEU701, LEU704, ASN705, LEU707, GLY708, GLN711, TRP741, MET742 and 11 more
  • 4OHA · Crystal structure of T877A-AR-LBD bound with co-regulator peptide · HFT A1001 · binds LEU701, LEU704, ASN705, LEU707, GLY708, GLN711, MET742, MET745 and 9 more
  • 4OIL · Crystal structure of T877A-AR-LBD bound with co-regulator peptide · HFT A1001 · binds LEU701, LEU704, ASN705, LEU707, GLY708, GLN711, MET742, MET745 and 9 more
  • 4OIU · Crystal structure of T877A-AR-LBD bound with co-regulator peptide · HFT A1001 · binds LEU701, LEU704, ASN705, LEU707, GLY708, GLN711, MET742, MET745 and 8 more
  • 4OJ9 · Crystal structure of T877A-AR-LBD bound with co-regulator peptide · HFT A1001 · binds LEU701, LEU704, ASN705, LEU707, GLY708, GLN711, MET742, MET745 and 8 more
  • 2AX6 · Crystal structure of the androgen receptor ligand binding domain T877A mutant in complex… · HFT A1 · binds LEU701, LEU704, ASN705, LEU707, GLY708, GLN711, MET742, MET745 and 10 more
  • 4OGH · Crystal structure of T877A-ar-lbd · HFT A1001 · binds LEU701, LEU704, ASN705, LEU707, GLY708, GLN711, MET742, MET745 and 7 more
  • 4OH5 · Crystal structure of T877A-ar-lbd bound with co-regulator peptide · HFT A1001 · binds LEU701, LEU704, ASN705, LEU707, GLY708, GLN711, MET742, MET745 and 9 more
  • 4OH6 · Crystal structure of T877A-ar-lbd bound with co-regulator peptide · HFT A1001 · binds LEU701, LEU704, ASN705, LEU707, GLY708, GLN711, TRP741, MET742 and 11 more
  • 4OHA · Crystal structure of T877A-ar-lbd bound with co-regulator peptide · HFT A1001 · binds LEU701, LEU704, ASN705, LEU707, GLY708, GLN711, MET742, MET745 and 9 more
  • 4OIL · Crystal structure of T877A-ar-lbd bound with co-regulator peptide · HFT A1001 · binds LEU701, LEU704, ASN705, LEU707, GLY708, GLN711, MET742, MET745 and 9 more
  • 4OIU · Crystal structure of T877A-ar-lbd bound with co-regulator peptide · HFT A1001 · binds LEU701, LEU704, ASN705, LEU707, GLY708, GLN711, MET742, MET745 and 8 more
  • 4OJ9 · Crystal structure of T877A-ar-lbd bound with co-regulator peptide · HFT A1001 · binds LEU701, LEU704, ASN705, LEU707, GLY708, GLN711, MET742, MET745 and 8 more

Residues it binds most

MET 16, LEU 16, PHE 16, ALA 16, ARG 16, ASN 16, GLN 16, GLY 16, VAL 16, ILE 8 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion
  • GOL · Glycerol

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