Research workbench
Crystal structure of the editing domain of E. COLI leucyl-tRNA synthetase
Analyse Crystal structure of the editing domain of E. COLI leucyl-tRNA synthetase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2AJG
- Type
- protein
- Length
- 360 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Leucyl-tRNA synthetase
- EC
- 6.1.1.4
- UniProt
- P07813
- Pockets
- 5 · best druggability 0.69
Structure
x-ray diffraction · 2 distinct chains · 31% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Leucyl-tRNA synthetase (EC 6.1.1.4) | protein | 186 | 31% helix, 24% strand | P07813 |
| B | Leucyl-tRNA synthetase (EC 6.1.1.4) | protein | 174 | 30% helix, 24% strand | P07813 |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 382 | 0.69 | 0.81 | 35 | empty |
| 2 | 161 | 0.46 | 0.76 | 22 | empty |
| 3 | 106 | 0.44 | 0.78 | 28 | empty |
| 4 | 63 | 0.30 | 0.74 | 14 | empty |
| 5 | 59 | 0.27 | 0.73 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 549 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 2AJG · Crystal structure of the editing domain of E. coli leucyl-tRNA synthetase · the same entry in another collection · chain A against A, TM-score 1.00
- P07813 · AlphaFold monomer V2.0 prediction for leucine--tRNA ligase (P07813) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07813
- Elsewhere: RCSB PDB 2AJG · PDBe 2AJG · UniProt P07813
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