MolNFT v1 · #450031 · protein
AlphaFold monomer V2.0 prediction for leucine--tRNA ligase (P07813)
P07813: “AlphaFold monomer V2.0 prediction for leucine--tRNA ligase (P07813)”. 6 pockets (best druggability 0.74). MolNFT v1 #450031 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P07813
- Type
- protein
- Length
- 860 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xb4D2d9c96b0D792d0b77e7147D724cc1F801ae58
- Molecule
- Leucine--tRNA ligase
- UniProt
- P07813
- Pockets
- 6 · best druggability 0.74
Structure
1 distinct chain · 39% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Leucine--tRNA ligase | protein | 860 | 39% helix, 22% strand | P07813 |
Pockets
6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 647 | 0.74 | 0.81 | 59 | empty |
| 2 | 686 | 0.74 | 0.80 | 57 | empty |
| 3 | 275 | 0.63 | 0.81 | 27 | empty |
| 4 | 88 | 0.51 | 0.83 | 16 | empty |
| 5 | 104 | 0.36 | 0.74 | 21 | empty |
Compared structures
- 5ON2 · Quaternary complex of mutant T252A of E. COLI leucyl-tRNA synthetase with TRNA(LEU)… · an experimental structure of the same protein · chain A against D, TM-score 0.91
- 5ON2 · Quaternary complex of mutant T252A of E. coli leucyl-tRNA synthetase with tRNA(leu)… · an experimental structure of the same protein · chain A against D, TM-score 0.91
- 3ZGZ · Ternary complex of E. coli leucyl-tRNA synthetase, tRNA(leu) and toxic moiety from… · an experimental structure of the same protein · chain A against D, TM-score 0.90
- 3ZGZ · Ternary complex of E. COLI leucyl-tRNA synthetase, TRNA(LEU) and toxic moiety from… · an experimental structure of the same protein · chain A against D, TM-score 0.90
- 5ON3 · Quaternary complex of mutant T252A of E. COLI leucyl-tRNA synthetase with TRNA(LEU)… · an experimental structure of the same protein · chain A against D, TM-score 0.89
- 5ON3 · Quaternary complex of mutant T252A of E. coli leucyl-tRNA synthetase with tRNA(leu)… · an experimental structure of the same protein · chain A against D, TM-score 0.89
- 4AQ7 · Ternary complex of E. coli leucyl-tRNA synthetase, tRNA(leu) and leucyl-adenylate… · an experimental structure of the same protein · chain A against A, TM-score 0.89
- 4AQ7 · Ternary complex of E. COLI leucyl-tRNA synthetase, TRNA(LEU) and leucyl-adenylate… · an experimental structure of the same protein · chain A against A, TM-score 0.89
- 5OMW · Mutant T252A of E. COLI leucyl-tRNA synthetase, TRNA(LEU) and leucyl- adenylate analogue… · an experimental structure of the same protein · chain A against A, TM-score 0.88
- 5OMW · Mutant T252A of E. coli leucyl-tRNA synthetase, tRNA(leu) and leucyl-adenylate analogue… · an experimental structure of the same protein · chain A against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07813
- Elsewhere: UniProt P07813 · AlphaFold DB P07813
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