Research workbench
Crystal structure of benzamidine-factor VIIA/SOLUBLE tissue factor complex.
Analyse Crystal structure of benzamidine-factor VIIA/SOLUBLE tissue factor complex. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2AER
- Type
- protein
- Length
- 588 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Coagulation factor VII; Tissue factor
- EC
- 3.4.21.21
- UniProt
- P08709, P13726
- Ligands
- BEN, GLC, FUC, CA, MG, ZN, NA, CL
- Pockets
- 9 · best druggability 0.57
Structure
x-ray diffraction · 3 distinct chains · 16% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | Coagulation factor VII | protein | 142 | 30% helix, 17% strand | P08709 |
| H | Coagulation factor VII (EC 3.4.21.21) | protein | 254 | 15% helix, 37% strand | P08709 |
| T | Tissue factor | protein | 192 | 8% helix, 49% strand | P13726 |
Ligands and binding sites
- BEN · Benzamidine · ligand · chains H
- GLC · alpha-D-glucopyranose · sugar · chains L
- FUC · alpha-L-fucopyranose · sugar · chains L, T
- CA · Calcium ion · metal · 6 copies · chains L, H
- MG · Magnesium ion · metal · 3 copies · chains L
- ZN · Zinc ion · metal · 2 copies · chains H
- NA · Sodium ion · metal · chains H
- CL · Chloride ion · ion · 3 copies · chains H, T
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 210 | 0.57 | 0.80 | 32 | empty |
| 2 | 51 | 0.55 | 0.90 | 17 | empty |
| 3 | 92 | 0.52 | 0.83 | 17 | empty |
| 4 | 157 | 0.47 | 0.77 | 23 | empty |
| 5 | 117 | 0.45 | 0.78 | 23 | empty |
Interfaces
3 interfaces between chains.
- L–T · 1380 Ų buried · 14 hydrogen bonds · protein-protein
- L–H · 1035 Ų buried · 15 hydrogen bonds · protein-protein
- H–T · 627 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 14 disulfide, 10 modified (disulfide, carboxylation).
Compared structures
- 2AER · Crystal Structure of Benzamidine-Factor VIIa/Soluble Tissue Factor complex. · the same entry in another collection · chain L against L, TM-score 1.00
- P13726 · AlphaFold monomer V2.0 prediction for tissue factor (P13726) · a predicted model of the same protein · chain T against A, TM-score 0.98
- P08709 · AlphaFold monomer V2.0 prediction for coagulation factor VII (P08709) · a predicted model of the same protein · chain H against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08709
- Every structure of UniProt P13726
- Elsewhere: RCSB PDB 2AER · PDBe 2AER · UniProt P08709 · UniProt P13726
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