UniProt P08709
Coagulation factor VII Light Chain (P08709)
Coagulation factor VII Light Chain (UniProt P08709), EC 3.4.21.21: 187 experimental structures and 1 predicted model on GenesisL1, 48 ligands bound, 36 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P08709
- Protein
- Coagulation factor VII Light Chain
- EC
- 3.4.21.21
- Experimental structures
- 187
- Predicted models
- 1
- Ligands
- 48
- Pockets
- 36 · 6 records with a druggable one
Structures
188 records of P08709 in the MolNFT archive: 187 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1BF9 | N-terminal EGF-like domain from human factor VII, NMR, 23 structures | solution nmr | A | — | — |
| 1BF9 | N-terminal EGF-like domain from human factor VII, NMR, 23 structures | solution nmr | A | — | — |
| 1CVW | Crystal structure of active site-inhibited human coagulation factor VIIA (DES-GLA) | x-ray diffraction | L, H | — | — |
| 1CVW | Crystal structure of active site-inhibited human coagulation factor viia (des-gla) | x-ray diffraction | L, H | — | — |
| 1DAN | Complex of active site inhibited human blood coagulation factor VIIA with human recombinant soluble… | x-ray diffraction | L, H | — | — |
| 1DAN | Complex of active site inhibited human blood coagulation factor viia with human recombinant soluble… | x-ray diffraction | L, H | — | — |
| 1DVA | Crystal Structure of the Complex Between the Peptide Exosite Inhibitor E-76 and Coagulation Factor… | x-ray diffraction | H, L, I, M | — | — |
| 1DVA | Crystal structure of the complex between the peptide exosite inhibitor E-76 and coagulation factor… | x-ray diffraction | H, L, I, M | — | — |
| 1F7E | The first EGF-like domain from human blood coagulation fvii, NMR, 20 structures | solution nmr | A | — | — |
| 1F7E | The first EGF-like domain from human blood coagulation fvii, NMR, 20 structures | solution nmr | A | — | — |
| 1F7M | The first EGF-like domain from human blood coagulation fvii, NMR, minimized average structure | solution nmr | A | — | — |
| 1F7M | The first EGF-like domain from human blood coagulation fvii, NMR, minimized average structure | solution nmr | A | — | — |
| 1FAK | Human tissue factor complexed with coagulation factor viia inhibited with a bpti-mutant | x-ray diffraction | L, H | — | — |
| 1FAK | Human tissue factor complexed with coagulation factor viia inhibited with a bpti-mutant | x-ray diffraction | L, H | — | — |
| 1FF7 | The first EGF-like domain from human blood coagulation fvii (fucosylated at ser-60), NMR, 20… | solution nmr | A | — | — |
| 1FF7 | The first EGF-like domain from human blood coagulation fvii (fucosylated at ser-60), NMR, 20… | solution nmr | A | — | — |
| 1FFM | The first EGF-like domain from human blood coagulation fvii (fucosylated at ser-60), NMR, minimized… | solution nmr | A | — | — |
| 1FFM | The first EGF-like domain from human blood coagulation fvii (fucosylated at ser-60), NMR, minimized… | solution nmr | A | — | — |
| 1J9C | Crystal Structure of tissue factor-factor VIIa complex | x-ray diffraction | L, H | — | — |
| 1J9C | Crystal structure of tissue factor-factor viia complex | x-ray diffraction | L, H | — | — |
| 1JBU | Coagulation Factor VII Zymogen (EGF2/Protease) in Complex with Inhibitory Exosite Peptide A-183 | x-ray diffraction | H, L | — | — |
| 1JBU | Coagulation factor VII zymogen (EGF2/PROTEASE) in complex with inhibitory exosite peptide a-183 | x-ray diffraction | H, L | — | — |
| 1KLI | Cofactor-and substrate-assisted activation of factor VIIa | x-ray diffraction | L, H | — | — |
| 1KLI | Cofactor-and substrate-assisted activation of factor viia | x-ray diffraction | L, H | — | — |
| 1KLJ | Crystal structure of uninhibited factor VIIa | x-ray diffraction | L, H | — | — |
| 1KLJ | Crystal structure of uninhibited factor viia | x-ray diffraction | L, H | — | — |
| 1O5D | Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial… | x-ray diffraction | L, H | — | — |
| 1O5D | Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial… | x-ray diffraction | L, H | — | — |
| 1QFK | Structure of human factor viia and its implications for the triggering of blood coagulation | x-ray diffraction | L, H | — | — |
| 1QFK | Structure of human factor viia and its implications for the triggering of blood coagulation | x-ray diffraction | L, H | — | — |
| 1W0Y | tf7a_3771 complex | x-ray diffraction | H, L | — | — |
| 1W0Y | TF7A_3771 complex | x-ray diffraction | H, L | — | — |
| 1W2K | tf7a_4380 complex | x-ray diffraction | H, L | — | — |
| 1W2K | TF7A_4380 complex | x-ray diffraction | H, L | — | — |
| 1W7X | Factor7 - 413 complex | x-ray diffraction | H, L | — | — |
| 1W7X | FACTOR7 - 413 complex | x-ray diffraction | H, L | — | — |
| 1W8B | Factor7 - 413 complex | x-ray diffraction | H, L | — | — |
| 1W8B | FACTOR7 - 413 complex | x-ray diffraction | H, L | — | — |
| 1WQV | Human Factor Viia-Tissue Factor Complexed with propylsulfonamide-D-Thr-Met-p-aminobenzamidine | x-ray diffraction | L, H | — | — |
| 1WQV | Human factor viia-tissue factor complexed with propylsulfonamide-D- thr-met-P-aminobenzamidine | x-ray diffraction | L, H | — | — |
| 1WSS | Human Factor Viia-Tissue Factor in Complex with peptide-mimetic inhibitor that has two charged… | x-ray diffraction | L, H | — | — |
| 1WSS | Human factor viia-tissue factor in complex with peptide-mimetic inhibitor that has two charged… | x-ray diffraction | L, H | — | — |
| 1WTG | Human Factor Viia-Tissue Factor Complexed with ethylsulfonamide-D-biphenylalanine-Gln-p-aminobenzami… | x-ray diffraction | L, H | — | — |
| 1WTG | Human factor viia-tissue factor complexed with ethylsulfonamide-D… | x-ray diffraction | L, H | — | — |
| 1WUN | Human Factor Viia-Tissue Factor Complexed with ethylsulfonamide-D-Trp-Gln-p-aminobenzamidine | x-ray diffraction | L, H | — | — |
| 1WUN | Human factor viia-tissue factor complexed with ethylsulfonamide-D-TRP- gln-P-aminobenzamidine | x-ray diffraction | L, H | — | — |
| 1WV7 | Human Factor Viia-Tissue Factor Complexed with ethylsulfonamide-D-5-propoxy-Trp-Gln-p-aminobenzamidi… | x-ray diffraction | L, H | — | — |
| 1WV7 | Human factor viia-tissue factor complexed with ethylsulfonamide-D-5… | x-ray diffraction | L, H | — | — |
| 1YGC | Short Factor VIIa with a small molecule inhibitor | x-ray diffraction | H, L | — | — |
| 1YGC | Short factor viia with a small molecule inhibitor | x-ray diffraction | H, L | — | — |
| 1Z6J | Crystal Structure of a ternary complex of Factor VIIa/Tissue Factor/Pyrazi Inhibitor | x-ray diffraction | L, H | — | — |
| 1Z6J | Crystal structure of a ternary complex of factor VIIA/TISSUE FACTOR/PYRAZINONE inhibitor | x-ray diffraction | L, H | — | — |
| 2A2Q | Complex of Active-site Inhibited Human Coagulation Factor VIIa with Human Soluble Tissue Factor in… | x-ray diffraction | L, H | — | — |
| 2A2Q | Complex of active-site inhibited human coagulation factor viia with human soluble tissue factor in… | x-ray diffraction | L, H | — | — |
| 2AEI | Crystal structure of a ternary complex of factor VIIa/tissue factor and… | x-ray diffraction | L, H | — | — |
| 2AEI | Crystal structure of a ternary complex of factor VIIA/TISSUE factor and… | x-ray diffraction | L, H | — | — |
| 2AER | Crystal Structure of Benzamidine-Factor VIIa/Soluble Tissue Factor complex. | x-ray diffraction | L, H | — | — |
| 2AER | Crystal structure of benzamidine-factor VIIA/SOLUBLE tissue factor complex. | x-ray diffraction | L, H | — | — |
| 2B7D | Factor VIIa Inhibitors: Chemical Optimization, Preclinical Pharmacokinetics, Pharmacodynamics, and… | x-ray diffraction | L, H | — | — |
| 2B7D | Factor viia inhibitors: chemical optimization, preclinical pharmacokinetics, pharmacodynamics, and… | x-ray diffraction | L, H | — | — |
128 records more on the page itself.
Ligands
- CA · Calcium ion · in 50 records
- SO4 · Sulfate ion · in 47 records
- CL · Chloride ion · in 36 records
- FUC · alpha-L-fucopyranose · in 3 records
- 70C · 1-[(2R,15R)-2-[(1-amino-4-fluoroisoquinolin-6-yl) amino]-4,15,17-trimethyl-3,12-dioxo-13-oxa-4,11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6(21),7,9, 16,19-hexaen-7-yl]cyclohexane-1-carboxylic acid · in 2 records
- 7XD · 1-[[3-[2-oxidanyl-3-(1~{H}-pyrrolo[3,2-c]pyridin-2-yl) phenyl]phenyl]methyl]-3-phenyl-urea · in 2 records
- 7XJ · 1-(1-azanylisoquinolin-6-yl)-3-(phenylmethyl)urea · in 2 records
- 7XM · isoquinoline-1,6-diamine · in 2 records
- 7YJ · (2R)-2-hydroxy-N-[[3-[5-hydroxy-4-(1H-pyrrolo[3,2-c]pyridin-2-yl)pyrazol-1-yl]phenyl]methyl]-3-methylbutanamide · in 2 records
- 7YM · N-(2-amino-1H-benzimidazol-5-yl)-1-[3-[[(3,5-dimethyl-1,2-oxazol-4-yl)carbamoylamino]methyl]phenyl]-5-hydroxypyrazole-4-carboxamide · in 2 records
- 7Z4 · 5-hydroxy-N-(1-oxo-1H-isoindol-6-yl)-1-(3-{[(phenylcarbamoyl)amino]methyl}phenyl)-1H-pyrazole-4-carboxamide · in 2 records
- 7Z7 · (2S)-2,3-dihydroxy-N-[[3-[5-hydroxy-4-(1H-pyrrolo[3,2-c]pyridin-2-yl)pyrazol-1-yl]phenyl]methyl]propanamide · in 2 records
- 7ZD · (2S)-2-hydroxy-N-[[3-[5-hydroxy-4-(1H-pyrrolo[3,2-c]pyridin-2-yl)pyrazol-1-yl]phenyl]methyl]-3-phenylpropanamide · in 2 records
- 82J · 3-{[(2R)-17-ethyl-4-methyl-3,12-dioxo-7-[(propan-2-yl) sulfonyl]-13-oxa-4,11-diazatricyclo[14.2.2.1~6, 10~]henicosa-1(18),6(21),7,9,16,19-hexaen-2-yl]amino}benzamide · in 2 records
- BGC · beta-D-glucopyranose · in 2 records
- 0Z6 · D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-phenylalaninamide · in 1 record
- 0Z7 · N-acetyl-D-phenylalanyl-N-[(2S,3S)-6-carbamimidamido-1-chloro-2-hydroxyhexan-3-yl]-L-phenylalaninamide · in 1 record
- 70A · (2R,15R)-2-[(1-aminoisoquinolin-6-yl)amino]-4,15,17-trimethyl-7-[1-(1H-tetrazol-5-yl)cyclopropyl]-13-oxa-4,11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18), 6(21),7,9,16,19-hexaene-3,12-dione · in 1 record
- 70D · 1-[(2R,15R)-2-[(1-amino-4-fluoroisoquinolin-6-yl) amino]-4,15,17-trimethyl-3,12-dioxo-13-oxa-4,11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6(21),7,9, 16,19-hexaen-7-yl]cyclobutane-1-carboxylic acid · in 1 record
- 7KQ · (5R)-5-[(1-aminoisoquinolin-6-yl)amino]-19-(cyclopropylsulfonyl)-3-methyl-13-oxa-3,15-diazatricyclo[14.3.1.1~6,10~]henicosa-1(20),6(21),7,9, 16,18-hexaene-4,14-dione · in 1 record
- 7KR · (11R)-11-[(1-aminoisoquinolin-6-yl)amino]-16-(cyclopropylsulfonyl)-13-methyl-2,13-diazatricyclo[13.3.1.1~6,10~]icosa-1(19),6(20),7,9,15, 17-hexaene-3,12-dione · in 1 record
- 7KS · (5R,11R)-11-[(1-amino-4-fluoroisoquinolin-6-yl)amino]-16-(cyclopropylsulfonyl)-7-(2,2-difluoroethoxy)-5,13-dimethyl-2,13-diazatricyclo[13.3.1.1~6,10~]icosa-1(19),6(20),7,9,15,17-hexaene-3,12-dione · in 1 record
- 7LR · N-(2-amino-1H-benzimidazol-5-yl)-2-[3-[(2-amino-2-oxoethyl)-methylsulfonylamino]-5-chlorophenyl]acetamide · in 1 record
- 7LX · (2~{R})-2-(4-ethoxy-3-methoxy-phenyl)-2-(isoquinolin-6-ylamino)ethanoic acid · in 1 record
- 7Y7 · 5-hydroxy-N-(4-oxo-3H-quinazolin-6-yl)-1-[3-[(phenylcarbamoylamino)methyl]phenyl]pyrazole-4-carboxamide · in 1 record
- 7YA · (2S)-2-hydroxy-N-[[3-[5-hydroxy-4-(1H-pyrrolo[3,2-c]pyridin-2-yl)pyrazol-1-yl]phenyl]methyl]propanamide · in 1 record
- 7YP · (2~{S})-~{N}-[[4-(aminomethyl)-2-(2-azanyl-2-oxidanylidene-ethoxy)phenyl]methyl]-2-(4-hydroxyphenyl)-2-methoxy-ethanami de · in 1 record
- 7Z1 · (2~{R})-2-[(1-azanylisoquinolin-6-yl)amino]-2-(5-ethoxy-2-fluoranyl-phenyl)-1-[(2~{R})-2-phenylpyrrolidin-1-yl]ethanone · in 1 record
- 7ZA · 2-[(1-aminoisoquinolin-6-yl)amino]-2-(3-ethoxy-4-propan-2-yloxyphenyl)-1-(2-phenylpyrrolidin-1-yl) ethanone · in 1 record
- 7ZG · N-(2-amino-1H-benzimidazol-5-yl)-2-(3-chlorophenyl) acetamide · in 1 record
Experiment against prediction
- 4YLQ chain H against the predicted model P08709: TM-score 0.98, RMSD 0.82 Å
- 4YLQ chain H against the predicted model P08709: TM-score 0.98, RMSD 0.82 Å
- 5PAF chain B against the predicted model P08709: TM-score 0.98, RMSD 0.80 Å
- 4X8S chain H against the predicted model P08709: TM-score 0.98, RMSD 0.81 Å
- 4X8S chain H against the predicted model P08709: TM-score 0.98, RMSD 0.81 Å
- 5PAU chain C against the predicted model P08709: TM-score 0.98, RMSD 0.81 Å
- 6R2W chain H against the predicted model P08709: TM-score 0.98, RMSD 0.83 Å
- 5PB1 chain D against the predicted model P08709: TM-score 0.98, RMSD 0.82 Å
- 4ZMA chain H against the predicted model P08709: TM-score 0.98, RMSD 0.84 Å
- 4NG9 chain H against the predicted model P08709: TM-score 0.98, RMSD 0.83 Å
Elsewhere
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