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Solution structure of polypyrimidine tract binding protein RBD34 complexed with cucucu RNA
Analyse Solution structure of polypyrimidine tract binding protein RBD34 complexed with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2ADC
- Type
- protein + RNA
- Length
- 220 residues
- Chains
- 3
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 5'-R(*CP*UP*CP*UP*CP*U)-3'; Polypyrimidine tract-binding protein 1
- UniProt
- P26599
- Pockets
- 2 · best druggability 0.63
Structure
solution nmr · 2 distinct chains · 24% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B, C | 5'-R(*CP*UP*CP*UP*CP*U)-3' | rna | 6 | — | — |
| A | Polypyrimidine tract-binding protein 1 | protein | 208 | 24% helix, 22% strand | P26599 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 102 | 0.63 | 0.89 | 18 | empty |
| 2 | 56 | 0.28 | 0.75 | 12 | empty |
Interfaces
2 interfaces between chains.
- B–A · 879 Ų buried · 25 hydrogen bonds · protein-nucleic
- C–A · 768 Ų buried · 17 hydrogen bonds · protein-nucleic
Compared structures
- 2ADC · Solution structure of Polypyrimidine Tract Binding protein RBD34 complexed with CUCUCU RNA · the same entry in another collection · chain B against B, TM-score 1.00
- P26599 · AlphaFold monomer V2.0 prediction for polypyrimidine tract-binding protein 1 (P26599) · a predicted model of the same protein · chain A against A, TM-score 0.83
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P26599
- Elsewhere: RCSB PDB 2ADC · PDBe 2ADC · UniProt P26599
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