Research workbench

Solution structure of polypyrimidine tract binding protein RBD1 complexed with cucucu RNA

Analyse Solution structure of polypyrimidine tract binding protein RBD1 complexed with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2AD9
Type: protein + RNA
Length: 104 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 5'-R(*CP*UP*CP*UP*CP*U)-3'; Polypyrimidine tract-binding protein 1
UniProt: P26599
Pockets: 1 · best druggability 0.56

Structure

solution nmr · 2 distinct chains · 26% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	5'-R(CPUPCPUPCPU)-3'	rna	6	—	—
A	Polypyrimidine tract-binding protein 1	protein	98	26% helix, 21% strand	P26599

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	90	0.56	0.85	17	empty

Interfaces

1 interface between chains.

B–A · 674 Å² buried · 24 hydrogen bonds · protein-nucleic

Compared structures

2AD9 · Solution structure of Polypyrimidine Tract Binding protein RBD1 complexed with CUCUCU RNA · the same entry in another collection · chain B against B, TM-score 1.00
P26599 · AlphaFold monomer V2.0 prediction for polypyrimidine tract-binding protein 1 (P26599) · a predicted model of the same protein · chain A against A, TM-score 0.81

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P26599
Elsewhere: RCSB PDB 2AD9 · PDBe 2AD9 · UniProt P26599

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.