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Crystal structure of leutaa, a bacterial homolog of NA+/CL--dependent neurotransmitter transporters
Analyse Crystal structure of leutaa, a bacterial homolog of NA+/CL--dependent… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2A65
- Type
- protein
- Length
- 509 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- NA(+):NEUROTRANSMITTER symporter (snf family)
- UniProt
- O67854
- Ligands
- LEU, NA, CL
- Pockets
- 4 · best druggability 0.71
Structure
x-ray diffraction · 1 distinct chain · 77% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | NA(+):NEUROTRANSMITTER symporter (snf family) | protein | 509 | 77% helix, 1% strand | O67854 |
Ligands and binding sites
- LEU · Leucine · ligand · chains A
- NA · Sodium ion · metal · 2 copies · chains A
- CL · Chloride ion · ion · chains A
- BOG · octyl beta-D-glucopyranoside · additive · 5 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 604 | 0.71 | 0.79 | 52 | empty |
| 2 | 98 | 0.57 | 0.86 | 18 | empty |
| 3 | 77 | 0.43 | 0.79 | 13 | empty |
| 4 | 93 | 0.36 | 0.74 | 12 | empty |
Compared structures
- 2A65 · Crystal structure of LEUTAA, a bacterial homolog of Na+/Cl--dependent neurotransmitter… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O67854
- Elsewhere: RCSB PDB 2A65 · PDBe 2A65 · UniProt O67854
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