Research workbench
Crystal structure of the 20S proteasome from yeast in complex with the proteasome activator PA26 from trypanosome brucei at 3.2 ångströms resolution
Analyse Crystal structure of the 20S proteasome from yeast in complex with the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1Z7Q
- Type
- protein
- Length
- 9,590 residues
- Chains
- 42
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Proteasome component C7-alpha; Proteasome component Y7; Proteasome component Y13…
- EC
- 3.4.25.1
- UniProt
- P21243, P23639, P23638, P40303, P32379, P40302, P21242, P38624, P25043, P25451, P22141, P30656, P23724, P30657, Q9U8G2
- Pockets
- 20 · best druggability 0.85
Structure
x-ray diffraction · 15 distinct chains · 35% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, O | Proteasome component C7-alpha (EC 3.4.25.1) | protein | 243 | 37% helix, 19% strand | P21243 |
| B, P | Proteasome component Y7 (EC 3.4.25.1) | protein | 249 | 33% helix, 24% strand | P23639 |
| C, Q | Proteasome component Y13 (EC 3.4.25.1) | protein | 243 | 35% helix, 25% strand | P23638 |
| D, R | Proteasome component PRE6 (EC 3.4.25.1) | protein | 241 | 36% helix, 24% strand | P40303 |
| E, S | Proteasome component PUP2 (EC 3.4.25.1) | protein | 245 | 34% helix, 25% strand | P32379 |
| F, T | Proteasome component PRE5 (EC 3.4.25.1) | protein | 234 | 34% helix, 28% strand | P40302 |
| G, U | Proteasome component C1 (EC 3.4.25.1) | protein | 243 | 35% helix, 23% strand | P21242 |
| H, V | Proteasome component PRE3 (EC 3.4.25.1) | protein | 196 | 32% helix, 29% strand | P38624 |
| I, W | Proteasome component PUP1 (EC 3.4.25.1) | protein | 222 | 24% helix, 32% strand | P25043 |
| J, X | Proteasome component PUP3 (EC 3.4.25.1) | protein | 204 | 31% helix, 31% strand | P25451 |
| K, Y | Proteasome component C11 (EC 3.4.25.1) | protein | 198 | 33% helix, 33% strand | P22141 |
| L, Z | Proteasome component PRE2 (EC 3.4.25.1) | protein | 212 | 36% helix, 34% strand | P30656 |
| M, a | Potential proteasome component C5 (EC 3.4.25.1) | protein | 222 | 31% helix, 32% strand | P23724 |
| N, b | Proteasome component PRE4 (EC 3.4.25.1) | protein | 233 | 30% helix, 23% strand | P30657 |
| c, d, e, f, g, h, i, j, k, l, m, n, o, p | Proteasome activator protein PA26 | protein | 230 | 70% helix, 0% strand | Q9U8G2 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 906 | 0.85 | 0.87 | 106 | empty |
| 2 | 1121 | 0.84 | 0.85 | 112 | empty |
| 3 | 1058 | 0.84 | 0.85 | 112 | empty |
| 4 | 1133 | 0.84 | 0.85 | 133 | empty |
| 5 | 997 | 0.82 | 0.83 | 91 | empty |
Interfaces
132 interfaces between chains.
- f–g · 2307 Ų buried · 33 hydrogen bonds · protein-protein
- m–n · 2303 Ų buried · 33 hydrogen bonds · protein-protein
- g–h · 2234 Ų buried · 29 hydrogen bonds · protein-protein
- n–o · 2231 Ų buried · 29 hydrogen bonds · protein-protein
- o–p · 2185 Ų buried · 30 hydrogen bonds · protein-protein
Compared structures
- 1Z7Q · Crystal structure of the 20s proteasome from yeast in complex with the proteasome… · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P21243
- Every structure of UniProt P23639
- Every structure of UniProt P23638
- Every structure of UniProt P40303
- Every structure of UniProt P32379
- Every structure of UniProt P40302
- Every structure of UniProt P21242
- Every structure of UniProt P38624
- Every structure of UniProt P25043
- Every structure of UniProt P25451
- Every structure of UniProt P22141
- Every structure of UniProt P30656
- Every structure of UniProt P23724
- Every structure of UniProt P30657
- Every structure of UniProt Q9U8G2
- Elsewhere: RCSB PDB 1Z7Q · PDBe 1Z7Q · UniProt P21243 · UniProt P23639 · UniProt P23638 · UniProt P40303 · UniProt P32379 · UniProt P40302 · UniProt P21242 · UniProt P38624 · UniProt P25043 · UniProt P25451 · UniProt P22141 · UniProt P30656 · UniProt P23724 · UniProt P30657 · UniProt Q9U8G2
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