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GDP-bound RAB21 GTPase

Analyse GDP-bound RAB21 GTPase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1Z0I
Type: protein
Length: 158 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RAS-related protein rab-21
UniProt: Q9UL25
Ligands: GDP, MG
Pockets: 2 · best druggability 0.41

Structure

x-ray diffraction · 1 distinct chain · 35% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RAS-related protein rab-21	protein	158	35% helix, 28% strand	Q9UL25

Ligands and binding sites

GDP · Guanosine-5'-diphosphate · ligand · chains A
MG · Magnesium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	118	0.41	0.76	21	MG, GDP
2	50	0.29	0.75	14	empty

Compared structures

1Z0I · GDP-Bound Rab21 GTPase · the same entry in another collection · chain A against A, TM-score 1.00
Q9UL25 · AlphaFold monomer V2.0 prediction for RAS-related protein rab-21 (Q9UL25) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9UL25
Elsewhere: RCSB PDB 1Z0I · PDBe 1Z0I · UniProt Q9UL25

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