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Gppnhp-bound RAB5C G55Q mutant GTPase

Analyse Gppnhp-bound RAB5C G55Q mutant GTPase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1Z07
Type: protein
Length: 165 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RAS-related protein rab-5C
UniProt: P35278
Ligands: GNP, MG
Pockets: 1 · best druggability 0.50

Structure

x-ray diffraction · 1 distinct chain · 37% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RAS-related protein rab-5C	protein	165	37% helix, 27% strand	P35278

Ligands and binding sites

GNP · Phosphoaminophosphonic acid-guanylate ester · ligand · chains A
MG · Magnesium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	153	0.50	0.79	28	MG, GNP

Compared structures

1Z07 · GppNHp-Bound Rab5c G55Q mutant GTPase · the same entry in another collection · chain A against A, TM-score 1.00
P35278 · AlphaFold monomer V2.0 prediction for RAS-related protein rab-5C (P35278) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P35278
Elsewhere: RCSB PDB 1Z07 · PDBe 1Z07 · UniProt P35278

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