Research workbench
Complex androgen receptor lbd and RAC3 peptide
Analyse Complex androgen receptor lbd and RAC3 peptide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1XJ7
- Type
- protein
- Length
- 265 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Androgen receptor; RAC3 derived peptide
- UniProt
- P10275
- Ligands
- DHT
- Pockets
- 4 · best druggability 0.83
Structure
x-ray diffraction · 2 distinct chains · 62% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Androgen receptor | protein | 256 | 64% helix, 5% strand | P10275 |
| B | RAC3 derived peptide | protein | 9 | 0% helix, 0% strand | — |
Ligands and binding sites
- DHT · 5-alpha-dihydrotestosterone · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 190 | 0.83 | 0.97 | 22 | DHT |
| 2 | 151 | 0.63 | 0.85 | 26 | empty |
| 3 | 70 | 0.30 | 0.74 | 14 | empty |
| 4 | 53 | 0.30 | 0.76 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 541 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10275
- Elsewhere: RCSB PDB 1XJ7 · PDBe 1XJ7 · UniProt P10275
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