Research workbench
Structure of an E6AP-UBCH7 complex: insights into the ubiquitination pathway
Analyse Structure of an E6AP-UBCH7 complex: insights into the ubiquitination pathway in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1C4Z
- Type
- protein
- Length
- 1,194 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ubiquitin-protein ligase E3A; Ubiquitin conjugating enzyme E2
- EC
- 6.3.2.-, 6.3.2.19
- UniProt
- Q05086, P68036
- Pockets
- 19 · best druggability 0.82
Structure
x-ray diffraction · 2 distinct chains · 39% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Ubiquitin-protein ligase E3A (EC 6.3.2.-) | protein | 350 | 46% helix, 13% strand | Q05086 |
| D | Ubiquitin conjugating enzyme E2 (EC 6.3.2.19) | protein | 144 | 24% helix, 15% strand | P68036 |
Pockets
19 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 524 | 0.82 | 0.88 | 52 | empty |
| 2 | 998 | 0.82 | 0.83 | 81 | empty |
| 3 | 708 | 0.81 | 0.85 | 69 | empty |
| 4 | 446 | 0.77 | 0.86 | 53 | empty |
| 5 | 170 | 0.62 | 0.84 | 25 | empty |
Interfaces
4 interfaces between chains.
- A–C · 1297 Ų buried · 14 hydrogen bonds · protein-protein
- B–C · 1267 Ų buried · 16 hydrogen bonds · protein-protein
- A–B · 1203 Ų buried · 17 hydrogen bonds · protein-protein
- A–D · 858 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 1C4Z · Structure of an E6AP-UBCH7 complex: insights into the ubiquitination pathway · the same entry in another collection · chain A against A, TM-score 1.00
- P68036 · AlphaFold monomer V2.0 prediction for ubiquitin-conjugating enzyme E2 L3 (P68036) · a predicted model of the same protein · chain D against A, TM-score 0.95
- Q05086 · AlphaFold monomer V2.0 prediction for ubiquitin-protein ligase E3A (Q05086) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q05086
- Every structure of UniProt P68036
- Elsewhere: RCSB PDB 1C4Z · PDBe 1C4Z · UniProt Q05086 · UniProt P68036
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