UniProt Q05086
Ubiquitin-protein ligase E3A (Q05086)
Ubiquitin-protein ligase E3A (UniProt Q05086), EC 2.3.2.26: 25 experimental structures on GenesisL1, 3 ligands bound, 124 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q05086
- Protein
- Ubiquitin-protein ligase E3A
- EC
- 2.3.2.26
- Experimental structures
- 25
- Predicted models
- 0
- Ligands
- 3
- Pockets
- 124 · 8 records with a druggable one
Structures
25 records of Q05086 in the MolNFT archive: 25 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1C4Z | Structure of an E6AP-UBCH7 complex: insights into the ubiquitination pathway | x-ray diffraction | A, B, C | — | — |
| 1C4Z | Structure of an E6AP-UBCH7 complex: insights into the ubiquitination pathway | x-ray diffraction | A, B, C | — | — |
| 1D5F | Structure of E6AP: insights into ubiquitination pathway | x-ray diffraction | A, B, C | — | — |
| 1D5F | Structure of E6AP: insights into ubiquitination pathway | x-ray diffraction | A, B, C | — | — |
| 1EQX | Solution structure determination and mutational analysis of the papillomavirus E6-interacting… | solution nmr | A | — | — |
| 1EQX | Solution structure determination and mutational analysis of the papillomavirus E6-interacting… | solution nmr | A | — | — |
| 4GIZ | Crystal structure of full-length human papillomavirus oncoprotein E6 in complex with LXXLL peptide… | x-ray diffraction | A, B | — | — |
| 4GIZ | Crystal structure of full-length human papillomavirus oncoprotein E6 in complex with lxxll peptide… | x-ray diffraction | A, B | — | — |
| 6SJV | Structure of HPV18 E6 oncoprotein in complex with mutant E6AP LxxLL motif | x-ray diffraction | A | GLC, ZN | — |
| 6SJV | Structure of HPV18 E6 oncoprotein in complex with mutant E6AP lxxll motif | x-ray diffraction | A | GLC, ZN | — |
| 6SLM | Crystal structure of full-length HPV31 E6 oncoprotein in complex with LXXLL peptide of ubiquitin… | x-ray diffraction | A | GLC, ZN | 6 (best 0.70) |
| 6SLM | Crystal structure of full-length HPV31 E6 oncoprotein in complex with lxxll peptide of ubiquitin… | x-ray diffraction | A | GLC, ZN | — |
| 6TGK | Domain swapped E6AP C-lobe dimer | x-ray diffraction | C | CA | — |
| 6U19 | Solution Structure of the RAZUL domain from 26S proteasome subunit hRpn10/S5a complexed with the… | solution nmr | B | ZN | — |
| 6U19 | Solution structure of the razul domain from 26S proteasome subunit HRPN10/S5A complexed with the… | solution nmr | B | ZN | — |
| 7QPB | Catalytic C-lobe of the HECT-type ubiquitin ligase E6AP in complex with a hybrid foldamer-peptide… | x-ray diffraction | A, B, C, D | — | 5 (best 0.58) |
| 8ENP | UBE3A isoform 3 AZUL | solution nmr | A | ZN | — |
| 8EPT | UBE3A isoform 2 AZUL domain | solution nmr | A | ZN | — |
| 8JRN | Structure of E6AP-E6 complex in Att1 state | electron microscopy | C, A | — | 20 (best 0.79) |
| 8JRO | Structure of E6AP-E6 complex in Att2 state | electron microscopy | C, A | — | 20 (best 0.81) |
| 8JRP | Structure of E6AP-E6 complex in Att3 state | electron microscopy | A, C | — | 20 (best 0.80) |
| 8JRQ | Structure of E6AP-E6 complex in Det1 state | electron microscopy | A, C | — | 20 (best 0.79) |
| 8JRR | Structure of E6AP-E6 complex in Det2 state | electron microscopy | A, C | — | 18 (best 0.83) |
| 8R1G | Dimeric ternary structure of E6AP-E6-p53 | electron microscopy | A, D | — | 15 (best 0.87) |
| Q05086 | AlphaFold monomer V2.0 prediction for ubiquitin-protein ligase E3A (Q05086) | — | — | — |
Ligands
Experiment against prediction
- 6SLM chain A against the predicted model P0AEX9: TM-score 0.68, RMSD 0.56 Å
Elsewhere
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