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Alkaline phosphatase (N51MG)

Analyse Alkaline phosphatase (N51MG) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
1URB
Type
protein
Length
892 residues
Chains
2
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Alkaline phosphatase
EC
3.1.3.1
UniProt
P00634
Ligands
ZN, MG, PO4
Pockets
5 · best druggability 0.81

Structure

x-ray diffraction · 1 distinct chain · 31% helix, 21% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
A, BAlkaline phosphatase (EC 3.1.3.1)protein44631% helix, 21% strandP00634

Ligands and binding sites

  • ZN · Zinc ion · metal · 2 copies · chains A, B
  • MG · Magnesium ion · metal · 2 copies · chains A, B
  • PO4 · Phosphate ion · ion · 4 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
11250.810.9929empty
2620.530.8714empty
3540.500.8714empty
41370.370.7321PO4
5710.290.7323PO4

Interfaces

1 interface between chains.

  • A–B · 3936 Ų buried · 62 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

  • 1URB · Alkaline phosphatase (N51MG) · the same entry in another collection · chain A against A, TM-score 1.00
  • P00634 · AlphaFold monomer V2.0 prediction for alkaline phosphatase (P00634) · a predicted model of the same protein · chain A against A, TM-score 1.00

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