Research workbench
Crystal structure of the human CDK2 kinase complex with cell cycle-regulatory protein CKSHS1
Analyse Crystal structure of the human CDK2 kinase complex with cell cycle-regulatory… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1BUH
- Type
- protein
- Length
- 357 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein (CDK2 human); Protein (CKSHS1 human)
- UniProt
- P24941, P61024
- Pockets
- 4 · best druggability 0.72
Structure
x-ray diffraction · 2 distinct chains · 31% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein (CDK2 human) | protein | 287 | 35% helix, 17% strand | P24941 |
| B | Protein (CKSHS1 human) | protein | 70 | 14% helix, 31% strand | P61024 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 62 | 0.72 | 0.97 | 16 | empty |
| 2 | 276 | 0.68 | 0.83 | 33 | empty |
| 3 | 121 | 0.35 | 0.73 | 27 | empty |
| 4 | 67 | 0.31 | 0.74 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 698 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 1BUH · Crystal structure of the human CDK2 kinase complex with cell cycle-regulatory protein… · the same entry in another collection · chain A against A, TM-score 1.00
- P61024 · AlphaFold monomer V2.0 prediction for cyclin-dependent kinases regulatory subunit 1… · a predicted model of the same protein · chain B against A, TM-score 0.96
- P24941 · AlphaFold monomer V2.0 prediction for cyclin-dependent kinase 2 (P24941) · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P24941
- Every structure of UniProt P61024
- Elsewhere: RCSB PDB 1BUH · PDBe 1BUH · UniProt P24941 · UniProt P61024
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