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Crystal structure of human rantes mutant K45E

Analyse Crystal structure of human rantes mutant K45E in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1U4P
Type: protein
Length: 133 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Small inducible cytokine A5
UniProt: P13501

Structure

x-ray diffraction · 2 distinct chains · 17% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Small inducible cytokine A5	protein	67	16% helix, 28% strand	P13501
B	Small inducible cytokine A5	protein	66	17% helix, 29% strand	P13501

Ligands and binding sites

ACY · Acetic acid · additive · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

A–B · 820 Å² buried · 15 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

1U4P · Crystal Structure of human RANTES mutant K45E · the same entry in another collection · chain A against A, TM-score 1.00
P13501 · AlphaFold monomer V2.0 prediction for C-C motif chemokine 5 (P13501) · a predicted model of the same protein · chain B against A, TM-score 0.90

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P13501
Elsewhere: RCSB PDB 1U4P · PDBe 1U4P · UniProt P13501

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