Atomic structure of the trypsin-A90720A complex: a unified approach to structure and function

Structure

x-ray diffraction · 2 distinct chains · 10% helix, 34% strand (DSSP).

Ligands and binding sites

• OSL · (2R)-2-hydroxy-3-(sulfooxy)propanoic acid · ligand · chains A, B
• CA · Calcium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–B · 564 Ų buried · 17 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 disulfide, 1 covalent, 1 d-amino, 1 modified (disulfide, covalent ligand, D-amino acid, nonstandard).

Compared structures

• 1TPS · Atomic structure of the trypsin-A90720A complex: a unified approach to structure and… · the same entry in another collection · chain A against A, TM-score 1.00
• 1TNH · Prediction of novel serine protease inhibitors · a predicted model of the same protein · chain A against A, TM-score 1.00
• 1TNG · Prediction of novel serine protease inhibitors · a predicted model of the same protein · chain A against A, TM-score 1.00
• 1TNL · Prediction of novel serine protease inhibitors · a predicted model of the same protein · chain A against A, TM-score 1.00
• 1TNK · Prediction of novel serine protease inhibitors · a predicted model of the same protein · chain A against A, TM-score 1.00
• 1TNI · Prediction of novel serine protease inhibitors · a predicted model of the same protein · chain A against A, TM-score 1.00
• 1TNJ · Prediction of novel serine protease inhibitors · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P00760
• Elsewhere: RCSB PDB 1TPS · PDBe 1TPS · UniProt P00760