UniProt P00760
Cationic trypsin (P00760)
Cationic trypsin (UniProt P00760), EC 3.4.21.4: 1,027 experimental structures and 6 predicted models on GenesisL1, 53 ligands bound, 22 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P00760
- Protein
- Cationic trypsin
- EC
- 3.4.21.4
- Experimental structures
- 1,027
- Predicted models
- 6
- Ligands
- 53
- Pockets
- 22 · 1 record with a druggable one
Structures
1,033 records of P00760 in the MolNFT archive: 1027 experimental, 6 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1AQ7 | Trypsin with inhibitor aeruginosin 98-B | x-ray diffraction | A | — | — |
| 1AQ7 | Trypsin with inhibitor aeruginosin 98-B | x-ray diffraction | A | — | — |
| 1AUJ | Bovine trypsin complexed to meta-cyano-benzylic inhibitor | x-ray diffraction | A | — | — |
| 1AUJ | Bovine trypsin complexed to meta-cyano-benzylic inhibitor | x-ray diffraction | A | — | — |
| 1AZ8 | Bovine trypsin complexed to bis-phenylamidine inhibitor | x-ray diffraction | A | — | — |
| 1AZ8 | Bovine trypsin complexed to bis-phenylamidine inhibitor | x-ray diffraction | A | — | — |
| 1BJU | Beta-trypsin complexed with acpu | x-ray diffraction | A | — | — |
| 1BJU | Beta-trypsin complexed with acpu | x-ray diffraction | A | — | — |
| 1BJV | Beta-trypsin complexed with appu | x-ray diffraction | A | — | — |
| 1BJV | Beta-trypsin complexed with appu | x-ray diffraction | A | — | — |
| 1BTP | Unique binding of a novel synthetic inhibitor, N-[3-[4-[4-(amidinophenoxy)-CARBONYL]PHENYL]-2-methyl… | x-ray diffraction | A | — | — |
| 1BTP | Unique binding of a novel synthetic inhibitor, N-[3-[4-[4… | x-ray diffraction | A | — | — |
| 1BTW | Episelection: novel KI ~nanomolar inhibitors of serine proteases selected by binding or chemistry… | x-ray diffraction | A | — | — |
| 1BTW | Episelection: novel ki ~nanomolar inhibitors of serine proteases selected by binding or chemistry… | x-ray diffraction | A | — | — |
| 1BTX | Episelection: Novel Ki ~Nanomolar Inhibitors of Serine Proteases Selected by Binding or Chemistry… | x-ray diffraction | A | — | — |
| 1BTX | Episelection: novel ki ~nanomolar inhibitors of serine proteases selected by binding or chemistry… | x-ray diffraction | A | — | — |
| 1BTY | Crystal structure of beta-trypsin in complex with benzamidine | x-ray diffraction | A | — | — |
| 1BTY | Crystal structure of beta-trypsin in complex with benzamidine | x-ray diffraction | A | — | — |
| 1BTZ | Episelection: novel KI ~nanomolar inhibitors of serine proteases selected by binding or chemistry… | x-ray diffraction | A | — | — |
| 1BTZ | Episelection: novel ki ~nanomolar inhibitors of serine proteases selected by binding or chemistry… | x-ray diffraction | A | — | — |
| 1C1N | Recruiting zinc to mediate potent, specific inhibition of serine proteases | x-ray diffraction | A | — | — |
| 1C1N | Recruiting zinc to mediate potent, specific inhibition of serine proteases | x-ray diffraction | A | — | — |
| 1C1O | Recruiting zinc to mediate potent, specific inhibition of serine proteases | x-ray diffraction | A | — | — |
| 1C1O | Recruiting zinc to mediate potent, specific inhibition of serine proteases | x-ray diffraction | A | — | — |
| 1C1P | Recruiting zinc to mediate potent, specific inhibition of serine proteases | x-ray diffraction | A | — | — |
| 1C1P | Recruiting zinc to mediate potent, specific inhibition of serine proteases | x-ray diffraction | A | — | — |
| 1C1Q | Recruiting zinc to mediate potent, specific inhibition of serine proteases | x-ray diffraction | A | — | — |
| 1C1Q | Recruiting zinc to mediate potent, specific inhibition of serine proteases | x-ray diffraction | A | — | — |
| 1C1R | Recruiting zinc to mediate potent, specific inhibition of serine proteases | x-ray diffraction | A | — | — |
| 1C1R | Recruiting zinc to mediate potent, specific inhibition of serine proteases | x-ray diffraction | A | — | — |
| 1C1S | Recruiting zinc to mediate potent, specific inhibition of serine proteases | x-ray diffraction | A | — | — |
| 1C1S | Recruiting zinc to mediate potent, specific inhibition of serine proteases | x-ray diffraction | A | — | — |
| 1C1T | Recruiting zinc to mediate potent, specific inhibition of serine proteases | x-ray diffraction | A | — | — |
| 1C1T | Recruiting zinc to mediate potent, specific inhibition of serine proteases | x-ray diffraction | A | — | — |
| 1C2D | Recruiting zinc to mediate potent, specific inhibition of serine proteases | x-ray diffraction | A | — | — |
| 1C2D | Recruiting zinc to mediate potent, specific inhibition of serine proteases | x-ray diffraction | A | — | — |
| 1C2E | Recruiting zinc to mediate potent, specific inhibition of serine proteases | x-ray diffraction | A | — | — |
| 1C2E | Recruiting zinc to mediate potent, specific inhibition of serine proteases | x-ray diffraction | A | — | — |
| 1C2F | Recruiting zinc to mediate potent, specific inhibition of serine proteases | x-ray diffraction | A | — | — |
| 1C2F | Recruiting zinc to mediate potent, specific inhibition of serine proteases | x-ray diffraction | A | — | — |
| 1C2G | Recruiting zinc to mediate potent, specific inhibition of serine proteases | x-ray diffraction | A | — | — |
| 1C2G | Recruiting zinc to mediate potent, specific inhibition of serine proteases | x-ray diffraction | A | — | — |
| 1C2H | Recruiting zinc to mediate potent, specific inhibition of serine proteases | x-ray diffraction | A | — | — |
| 1C2H | Recruiting zinc to mediate potent, specific inhibition of serine proteases | x-ray diffraction | A | — | — |
| 1C2I | Recruiting zinc to mediate potent, specific inhibition of serine proteases | x-ray diffraction | A | — | — |
| 1C2I | Recruiting zinc to mediate potent, specific inhibition of serine proteases | x-ray diffraction | A | — | — |
| 1C2J | Recruiting zinc to mediate potent, specific inhibition of serine proteases | x-ray diffraction | A | — | — |
| 1C2J | Recruiting zinc to mediate potent, specific inhibition of serine proteases | x-ray diffraction | A | — | — |
| 1C2K | Recruiting zinc to mediate potent, specific inhibition of serine proteases | x-ray diffraction | A | — | — |
| 1C2K | Recruiting zinc to mediate potent, specific inhibition of serine proteases | x-ray diffraction | A | — | — |
| 1C2L | Recruiting zinc to mediate potent, specific inhibition of serine proteases | x-ray diffraction | A | — | — |
| 1C2L | Recruiting zinc to mediate potent, specific inhibition of serine proteases | x-ray diffraction | A | — | — |
| 1C2M | Recruiting zinc to mediate potent, specific inhibition of serine proteases | x-ray diffraction | A | — | — |
| 1C2M | Recruiting zinc to mediate potent, specific inhibition of serine proteases | x-ray diffraction | A | — | — |
| 1C5P | Structural basis for selectivity of a small molecule, S1-binding, sub-micromolar inhibitor of… | x-ray diffraction | A | — | — |
| 1C5P | Structural basis for selectivity of a small molecule, S1-binding, sub- micromolar inhibitor of… | x-ray diffraction | A | — | — |
| 1C5Q | Structural basis for selectivity of a small molecule, S1-binding, sub-micromolar inhibitor of… | x-ray diffraction | A | — | — |
| 1C5Q | Structural basis for selectivity of a small molecule, S1-binding, sub- micromolar inhibitor of… | x-ray diffraction | A | — | — |
| 1C5R | Structural basis for selectivity of a small molecule, S1-binding, sub-micromolar inhibitor of… | x-ray diffraction | A | — | — |
| 1C5R | Structural basis for selectivity of a small molecule, S1-binding, sub- micromolar inhibitor of… | x-ray diffraction | A | — | — |
973 records more on the page itself.
Ligands
- CA · Calcium ion · in 170 records
- SO4 · Sulfate ion · in 120 records
- BEN · Benzamidine · in 49 records
- 2AP · 2-aminopyridine · in 8 records
- XYS · alpha-D-xylopyranose · in 7 records
- D86 · [azanyl(piperidin-1-yl)methylidene]azanium · in 6 records
- NA · Sodium ion · in 6 records
- ABN · Benzylamine · in 5 records
- ANL · Aniline · in 5 records
- CL · Chloride ion · in 5 records
- F5R · 4-bromanylbenzenecarboximidamide · in 5 records
- MRZ · piperidine-1-carboximidamide · in 5 records
- SRO · Serotonin · in 5 records
- XYP · beta-D-xylopyranose · in 5 records
- 6SO · 2-(5-chloranyl-1~{H}-indol-3-yl)ethanamine · in 4 records
- UFZ · (phenylmethyl)azanium · in 4 records
- F05 · 1H-isoindol-3-amine · in 3 records
- 32U · D-phenylalanyl-N-{4-[amino(iminio)methyl]benzyl}-L-prolinamide · in 2 records
- 6VZ · (2~{S},4~{S})-1-[4-(aminomethyl)-3-methoxy-phenyl]carbonyl-4-[4-(2-cyclopropylethoxy)-6,8-dihydro-5~{H}-pyrido[3,4-d]pyrimidin-7-yl]-~{N}-methyl-pyrrolidine-2-carboxamide · in 2 records
- 6W4 · (2~{S},4~{S})-1-[4-(aminomethyl)phenyl]carbonyl-4-(4-cyclopropyl-1,2,3-triazol-1-yl)-~{N}-(2,2-diphenylethyl)pyrrolidine-2-carboxamide · in 2 records
- 6WH · (2~{S},4~{S})-1-[4-(aminomethyl)-3-methoxy-phenyl]carbonyl-4-(4-cyclopropyl-1,2,3-triazol-1-yl)-~{N}-[(1~{S},2~{R})-2-phenylcyclohexyl]pyrrolidine-2-carboxamide · in 2 records
- 8M2 · [azanyl(thiophen-3-yl)methylidene]azanium · in 2 records
- AMH · Trans-4-aminomethylcyclohexane-1-carboxylic acid · in 2 records
- DJY · 3-{2-[(4-carbamimidoylphenyl)carbamoyl]-4-ethenyl-5-methoxyphenyl}-6-[(cyclopropylmethyl) carbamoyl]pyridine-2-carboxylic acid · in 2 records
- F5U · 2-(5-methoxy-1H-indol-3-yl)ethanamine · in 2 records
- F5X · 2-(6-methoxy-1H-indol-3-yl)ethanamine · in 2 records
- F66 · 2-(2-methyl-1H-indol-3-yl)ethanamine · in 2 records
- J5K · (2~{S})-1-[(2~{R})-2-azanyl-3-phenyl-propanoyl]-~{N}-[(6-azanylpyridin-3-yl)methyl]pyrrolidine-2-carboxamide · in 2 records
- K73 · (2~{S})-~{N}-[[4-(aminomethyl)phenyl]methyl]-1-[(2~{R})-2-azanyl-3-phenyl-propanoyl]pyrrolidine-2-carboxamide · in 2 records
- LXW · (2~{S})-1-[(2~{R})-2-azanyl-3,3-diphenyl-propanoyl]-~{N}-(pyridin-4-ylmethyl)pyrrolidine-2-carboxamide · in 2 records
Experiment against prediction
- 5MOR chain A against the predicted model 1TNH: TM-score 1.00, RMSD 0.11 Å
- 5MOR chain A against the predicted model 1TNH: TM-score 1.00, RMSD 0.11 Å
- 5MNM chain A against the predicted model 1TNH: TM-score 1.00, RMSD 0.11 Å
- 5MNM chain A against the predicted model 1TNH: TM-score 1.00, RMSD 0.11 Å
- 7BRX chain A against the predicted model 1TNL: TM-score 1.00, RMSD 0.11 Å
- 7BRZ chain A against the predicted model 1TNL: TM-score 1.00, RMSD 0.12 Å
- 5MOP chain A against the predicted model 1TNL: TM-score 1.00, RMSD 0.12 Å
- 2OXS chain A against the predicted model 1TNL: TM-score 1.00, RMSD 0.12 Å
- 5MNZ chain A against the predicted model 1TNL: TM-score 1.00, RMSD 0.12 Å
- 5MOO chain A against the predicted model 1TNL: TM-score 1.00, RMSD 0.12 Å
Elsewhere
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